BTG1 [The Human Chemical-Genetic Interaction Map Project]

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======= BTG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BTG1
  * **<color #00a2e8>Official Name</color>**: BTG anti-proliferation factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=694|694]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62324|P62324]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BTG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BTG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109580|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Anti-proliferative protein. {ECO:0000269|PubMed:1373383}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of fibroblast apoptotic process|
|positive regulation of endothelial cell differentiation|
|regulation of fibroblast apoptotic process|
|positive regulation of myoblast differentiation|
|regulation of endothelial cell differentiation|
|regulation of myoblast differentiation|
|positive regulation of epithelial cell differentiation|
|transcription coregulator activity|
|kinase binding|
|protein alkylation|
|protein methylation|
|regulation of epithelial cell differentiation|
|positive regulation of angiogenesis|
|negative regulation of cell growth|
|positive regulation of vasculature development|
|negative regulation of growth|
|macromolecule methylation|
|regulation of angiogenesis|
|negative regulation of mitotic cell cycle|
|methylation|
|regulation of vasculature development|
|enzyme binding|
|response to oxidative stress|
|response to peptide hormone|
|regulation of cell growth|
|response to peptide|
|spermatogenesis|
|male gamete generation|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|negative regulation of cell population proliferation|
|gamete generation|
|positive regulation of cell death|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to hormone|
|cell migration|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|response to organonitrogen compound|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|regulation of cell cycle|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cnot8|CNOT8]]|0.608|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17766
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BTG1 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>