BTG2 [The Human Chemical-Genetic Interaction Map Project]

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======= BTG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BTG2
  * **<color #00a2e8>Official Name</color>**: BTG anti-proliferation factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7832|7832]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78543|P78543]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BTG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BTG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601597|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:18337750, ECO:0000269|PubMed:18773938, ECO:0000269|PubMed:23236473}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|dentate gyrus development|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|negative regulation of neural precursor cell proliferation|
|response to electrical stimulus|
|positive regulation of mRNA catabolic process|
|skeletal muscle cell differentiation|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|associative learning|
|positive regulation of mRNA metabolic process|
|DNA damage response, signal transduction by p53 class mediator|
|central nervous system neuron development|
|positive regulation of cell cycle arrest|
|hippocampus development|
|regulation of neural precursor cell proliferation|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|signal transduction in response to DNA damage|
|mitotic DNA integrity checkpoint|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|limbic system development|
|signal transduction by p53 class mediator|
|skeletal muscle tissue development|
|negative regulation of translation|
|DNA damage checkpoint|
|skeletal muscle organ development|
|protein alkylation|
|protein methylation|
|DNA integrity checkpoint|
|negative regulation of neuron apoptotic process|
|learning|
|negative regulation of cellular amide metabolic process|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|pallium development|
|central nervous system neuron differentiation|
|cell cycle checkpoint|
|regulation of mRNA catabolic process|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|response to mechanical stimulus|
|negative regulation of mitotic cell cycle phase transition|
|anterior/posterior pattern specification|
|negative regulation of cell cycle phase transition|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|macromolecule methylation|
|telencephalon development|
|learning or memory|
|striated muscle tissue development|
|positive regulation of cell cycle process|
|muscle organ development|
|muscle tissue development|
|cognition|
|negative regulation of mitotic cell cycle|
|regulation of neuron death|
|methylation|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|regionalization|
|regulation of translation|
|positive regulation of cellular catabolic process|
|positive regulation of cell cycle|
|forebrain development|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|pattern specification process|
|regulation of cell cycle phase transition|
|response to peptide|
|muscle structure development|
|DNA repair|
|posttranscriptional regulation of gene expression|
|behavior|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|neuron projection development|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|brain development|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|head development|
|neuron development|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|central nervous system development|
|negative regulation of cell death|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.1|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.86|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cnot8|CNOT8]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10337
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BTG2 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>