BUB1B [The Human Chemical-Genetic Interaction Map Project]

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======= BUB1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BUB1B
  * **<color #00a2e8>Official Name</color>**: BUB1 mitotic checkpoint serine/threonine kinase B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=701|701]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60566|O60566]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BUB1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BUB1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mad3 BUB1 I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic sister chromatid cohesion, centromeric|
|centromeric sister chromatid cohesion|
|meiotic sister chromatid segregation|
|meiotic sister chromatid cohesion|
|condensed nuclear chromosome kinetochore|
|meiosis II|
|meiosis II cell cycle process|
|condensed chromosome outer kinetochore|
|anaphase-promoting complex|
|mitotic spindle assembly checkpoint|
|spindle checkpoint|
|mitotic spindle checkpoint|
|spindle assembly checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|sister chromatid cohesion|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|chromosome organization involved in meiotic cell cycle|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|anaphase-promoting complex-dependent catabolic process|
|kinetochore|
|condensed chromosome kinetochore|
|meiotic chromosome segregation|
|regulation of chromosome segregation|
|spindle|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|meiotic nuclear division|
|mitotic cell cycle checkpoint|
|microtubule organizing center|
|meiotic cell cycle process|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|nuclear chromosome segregation|
|meiotic cell cycle|
|negative regulation of cell cycle phase transition|
|protein kinase activity|
|chromosome segregation|
|nuclear division|
|negative regulation of mitotic cell cycle|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|proteasomal protein catabolic process|
|regulation of chromosome organization|
|protein serine/threonine kinase activity|
|negative regulation of organelle organization|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|protein catabolic process|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|cellular macromolecule catabolic process|
|apoptotic process|
|protein phosphorylation|
|cell cycle process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|chromosome organization|
|cell death|
|regulation of cell cycle|
|proteolysis|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|ATP binding|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.82|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.55|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.41|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.34|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.33|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.32|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.23|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.04|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.88|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.86|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.88|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.26|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|3.54|
|[[:results:exp17|DABN 20μM R00 exp17]]|3.77|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|4.4|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|4.66|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|5.02|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|5.08|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|5.53|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|5.61|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|5.7|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|5.74|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|5.81|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|5.87|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|6.06|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|6.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mad1l1|MAD1L1]]|0.801|
|[[:human genes:m:mad2l1|MAD2L1]]|0.799|
|[[:human genes:k:kntc1|KNTC1]]|0.797|
|[[:human genes:z:zw10|ZW10]]|0.783|
|[[:human genes:t:trip13|TRIP13]]|0.752|
|[[:human genes:r:rbm14|RBM14]]|0.72|
|[[:human genes:z:zwilch|ZWILCH]]|0.698|
|[[:human genes:b:bub3|BUB3]]|0.663|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.656|
|[[:human genes:c:cdc20|CDC20]]|0.491|
|[[:human genes:f:fnta|FNTA]]|0.467|
|[[:human genes:f:fntb|FNTB]]|0.442|
|[[:human genes:c:ccnb1|CCNB1]]|0.44|
|[[:human genes:p:pelo|PELO]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 719/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|26/28|
|bone|25/26|
|breast|32/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2500
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BUB1B Expression in NALM6 Cells: 7.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>