BUD13 [The Human Chemical-Genetic Interaction Map Project]

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======= BUD13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BUD13
  * **<color #00a2e8>Official Name</color>**: BUD13 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84811|84811]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRD0|Q9BRD0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BUD13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BUD13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620691|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bud13|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RES complex|
|U2-type spliceosomal complex|
|U2-type precatalytic spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-2.15|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.98|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.95|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.95|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.93|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.84|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.82|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.84|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 144/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|6/28|
|blood|2/28|
|bone|9/26|
|breast|5/33|
|central nervous system|10/56|
|cervix|2/4|
|colorectal|1/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|6/21|
|liver|3/20|
|lung|10/75|
|lymphocyte|6/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|11/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3505
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BUD13 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>