C10orf76 [The Human Chemical-Genetic Interaction Map Project]

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======= C10orf76 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARMH3
  * **<color #00a2e8>Official Name</color>**: armadillo like helical domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79591|79591]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T2E6|Q5T2E6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C10orf76&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C10orf76|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620867|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1741|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-3.35|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-3.01|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.85|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.67|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.54|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.4|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.39|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.34|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.33|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.24|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.2|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.1|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.07|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.97|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.97|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.94|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.93|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.88|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.83|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.76|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.76|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.73|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.73|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.77|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.79|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.94|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pi4kb|PI4KB]]|0.482|
|[[:human genes:s:sptlc1|SPTLC1]]|0.451|
|[[:human genes:c:cog7|COG7]]|0.44|
|[[:human genes:s:sptlc2|SPTLC2]]|0.429|
|[[:human genes:c:cog5|COG5]]|0.425|
|[[:human genes:a:arl1|ARL1]]|0.425|
|[[:human genes:u:unc50|UNC50]]|0.422|
|[[:human genes:z:zfat|ZFAT]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10296
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C10ORF76 Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>