C12orf49 [The Human Chemical-Genetic Interaction Map Project]

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======= C12orf49 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C12orf49
  * **<color #00a2e8>Official Name</color>**: chromosome 12 open reading frame 49
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79794|79794]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H741|Q9H741]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C12orf49&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C12orf49|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2054|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-4.96|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-4.09|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.03|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.54|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.86|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.77|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.72|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.77|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.84|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.95|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.98|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.12|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.8|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.87|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.41|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|3.66|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|5.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:scap|SCAP]]|0.511|
|[[:human genes:u:unc50|UNC50]]|0.435|
|[[:human genes:s:srebf2|SREBF2]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18982
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C12orf49 Expression in NALM6 Cells: 9.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>