C14orf169 [The Human Chemical-Genetic Interaction Map Project]

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======= C14orf169 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIOX1
  * **<color #00a2e8>Official Name</color>**: ribosomal oxygenase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79697|79697]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6W3|Q9H6W3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C14orf169&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C14orf169|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611919|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC- induced transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone demethylase activity (H3-K4 specific)|
|histone H3-K4 demethylation|
|histone demethylase activity (H3-K36 specific)|
|histone H3-K36 demethylation|
|2-oxoglutarate-dependent dioxygenase activity|
|histone lysine demethylation|
|histone demethylation|
|protein dealkylation|
|protein demethylation|
|negative regulation of osteoblast differentiation|
|demethylation|
|negative regulation of ossification|
|regulation of osteoblast differentiation|
|iron ion binding|
|regulation of ossification|
|histone modification|
|covalent chromatin modification|
|chromatin organization|
|negative regulation of cell differentiation|
|nucleolus|
|negative regulation of developmental process|
|oxidation-reduction process|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.95|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.71|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.71|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.81|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.83|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.83|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.08|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.25|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.31|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.52|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17584
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C14ORF169 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>