C16orf45 [The Human Chemical-Genetic Interaction Map Project]

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======= C16orf45 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BMERB1
  * **<color #00a2e8>Official Name</color>**: bMERB domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=89927|89927]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96MC5|Q96MC5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C16orf45&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C16orf45|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3585|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell motility involved in cerebral cortex radial glia guided migration|
|negative regulation of glial cell migration|
|layer formation in cerebral cortex|
|regulation of glial cell migration|
|telencephalon glial cell migration|
|cerebral cortex radial glia guided migration|
|negative regulation of microtubule depolymerization|
|cerebral cortex radially oriented cell migration|
|regulation of microtubule depolymerization|
|glial cell migration|
|negative regulation of microtubule polymerization or depolymerization|
|negative regulation of gliogenesis|
|cerebral cortex cell migration|
|telencephalon cell migration|
|negative regulation of protein depolymerization|
|forebrain cell migration|
|negative regulation of protein complex disassembly|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|regulation of protein complex disassembly|
|regulation of gliogenesis|
|cerebral cortex development|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|microtubule cytoskeleton|
|pallium development|
|regulation of microtubule cytoskeleton organization|
|gliogenesis|
|regulation of microtubule-based process|
|telencephalon development|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|negative regulation of cell development|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|forebrain development|
|regulation of cytoskeleton organization|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|brain development|
|head development|
|regulation of neurogenesis|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|cell motility|
|localization of cell|
|negative regulation of multicellular organismal process|
|regulation of organelle organization|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.74|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.78|
|[[:results:exp302|35°C R06 exp302]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9618
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C16ORF45 Expression in NALM6 Cells: -0.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>