C17orf104 [The Human Chemical-Genetic Interaction Map Project]

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======= C17orf104 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEIOC
  * **<color #00a2e8>Official Name</color>**: meiosis specific with coiled-coil domain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=284071|284071]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A2RUB1|A2RUB1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C17orf104&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C17orf104|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616934|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle. {ECO:0000250|UniProtKB:A2AG06}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell cycle switching, mitotic to meiotic cell cycle|
|cell cycle switching|
|germline cell cycle switching, mitotic to meiotic cell cycle|
|female meiosis I|
|synaptonemal complex assembly|
|synaptonemal complex organization|
|male meiosis I|
|positive regulation of meiotic cell cycle|
|female meiotic nuclear division|
|oocyte development|
|mRNA stabilization|
|oocyte differentiation|
|synapsis|
|male meiotic nuclear division|
|RNA stabilization|
|regulation of meiotic cell cycle|
|negative regulation of mRNA catabolic process|
|metaphase plate congression|
|homologous chromosome segregation|
|negative regulation of RNA catabolic process|
|chromosome organization involved in meiotic cell cycle|
|establishment of chromosome localization|
|chromosome localization|
|positive regulation of reproductive process|
|oogenesis|
|negative regulation of mRNA metabolic process|
|meiotic chromosome segregation|
|meiosis I|
|meiosis I cell cycle process|
|female gamete generation|
|spermatid development|
|meiotic nuclear division|
|spermatid differentiation|
|regulation of reproductive process|
|meiotic cell cycle process|
|regulation of mRNA stability|
|double-strand break repair|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|nuclear chromosome segregation|
|meiotic cell cycle|
|negative regulation of cellular catabolic process|
|germ cell development|
|chromosome segregation|
|nuclear division|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|organelle fission|
|regulation of mRNA metabolic process|
|cellular process involved in reproduction in multicellular organism|
|establishment of organelle localization|
|positive regulation of cell cycle|
|DNA repair|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|male gamete generation|
|negative regulation of cell cycle|
|organelle localization|
|regulation of mitotic cell cycle|
|developmental process involved in reproduction|
|gamete generation|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|multi-organism reproductive process|
|regulation of catabolic process|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|negative regulation of RNA metabolic process|
|cell cycle|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|cell development|
|cellular response to stress|
|establishment of localization in cell|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.58|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.81|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.8|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.77|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12993
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C17ORF104 Expression in NALM6 Cells: 3.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>