C17orf89 [The Human Chemical-Genetic Interaction Map Project]

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======= C17orf89 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFAF8
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase complex assembly factor 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=284184|284184]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A1L188|A1L188]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C17orf89&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C17orf89|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) (PubMed:27499296). Required to stabilize NDUFAF5 (PubMed:27499296). {ECO:0000269|PubMed:27499296}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|mitochondrion|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.86|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.76|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.72|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.73|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.84|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.87|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.88|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.9|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.91|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.95|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.96|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.01|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.35|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.36|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.74|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.78|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnaseh1|RNASEH1]]|0.645|
|[[:human genes:n:ndufb5|NDUFB5]]|0.644|
|[[:human genes:y:yars2|YARS2]]|0.636|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.609|
|[[:human genes:m:mrps5|MRPS5]]|0.595|
|[[:human genes:n:ndufb11|NDUFB11]]|0.592|
|[[:human genes:n:ndufa3|NDUFA3]]|0.586|
|[[:human genes:m:mrpl21|MRPL21]]|0.583|
|[[:human genes:c:c12orf65|C12orf65]]|0.583|
|[[:human genes:n:ndufs7|NDUFS7]]|0.576|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.575|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.573|
|[[:human genes:r:rpusd4|RPUSD4]]|0.572|
|[[:human genes:g:gfm2|GFM2]]|0.571|
|[[:human genes:p:pdss1|PDSS1]]|0.567|
|[[:human genes:e:ecsit|ECSIT]]|0.566|
|[[:human genes:s:sars2|SARS2]]|0.563|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.558|
|[[:human genes:t:tmem242|TMEM242]]|0.557|
|[[:human genes:b:bcs1l|BCS1L]]|0.555|
|[[:human genes:m:mrpl23|MRPL23]]|0.548|
|[[:human genes:c:cox5a|COX5A]]|0.547|
|[[:human genes:c:c10orf2|C10orf2]]|0.543|
|[[:human genes:m:mrps21|MRPS21]]|0.542|
|[[:human genes:n:ndufa2|NDUFA2]]|0.54|
|[[:human genes:m:mrps34|MRPS34]]|0.538|
|[[:human genes:n:ndufb6|NDUFB6]]|0.537|
|[[:human genes:s:selrc1|SELRC1]]|0.533|
|[[:human genes:n:ndufc2|NDUFC2]]|0.533|
|[[:human genes:f:fh|FH]]|0.532|
|[[:human genes:m:mrpl55|MRPL55]]|0.532|
|[[:human genes:t:tmem126b|TMEM126B]]|0.525|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.522|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.522|
|[[:human genes:n:ndufb3|NDUFB3]]|0.522|
|[[:human genes:t:tars2|TARS2]]|0.522|
|[[:human genes:c:cox16|COX16]]|0.521|
|[[:human genes:m:mrps6|MRPS6]]|0.52|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.516|
|[[:human genes:n:ndufs2|NDUFS2]]|0.515|
|[[:human genes:s:slc25a26|SLC25A26]]|0.514|
|[[:human genes:m:mrpl53|MRPL53]]|0.514|
|[[:human genes:t:tpk1|TPK1]]|0.514|
|[[:human genes:n:ndufb9|NDUFB9]]|0.509|
|[[:human genes:m:mtg1|MTG1]]|0.509|
|[[:human genes:a:atp5d|ATP5D]]|0.508|
|[[:human genes:m:mrps16|MRPS16]]|0.508|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.508|
|[[:human genes:s:sco2|SCO2]]|0.508|
|[[:human genes:g:gfm1|GFM1]]|0.506|
|[[:human genes:m:mrps26|MRPS26]]|0.505|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.505|
|[[:human genes:m:mrpl15|MRPL15]]|0.504|
|[[:human genes:n:ndufa1|NDUFA1]]|0.504|
|[[:human genes:e:ears2|EARS2]]|0.504|
|[[:human genes:m:mtpap|MTPAP]]|0.504|
|[[:human genes:q:qrsl1|QRSL1]]|0.502|
|[[:human genes:r:rbfa|RBFA]]|0.499|
|[[:human genes:m:mrps14|MRPS14]]|0.498|
|[[:human genes:c:cox6c|COX6C]]|0.497|
|[[:human genes:n:ndufa10|NDUFA10]]|0.497|
|[[:human genes:g:gatc|GATC]]|0.497|
|[[:human genes:t:tufm|TUFM]]|0.496|
|[[:human genes:n:nfu1|NFU1]]|0.493|
|[[:human genes:n:ndufs8|NDUFS8]]|0.493|
|[[:human genes:p:polg|POLG]]|0.493|
|[[:human genes:v:vars2|VARS2]]|0.492|
|[[:human genes:a:acad9|ACAD9]]|0.492|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.491|
|[[:human genes:t:tefm|TEFM]]|0.489|
|[[:human genes:g:grsf1|GRSF1]]|0.486|
|[[:human genes:n:ndufa11|NDUFA11]]|0.484|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.482|
|[[:human genes:i:iba57|IBA57]]|0.482|
|[[:human genes:m:mrps33|MRPS33]]|0.48|
|[[:human genes:m:mrpl47|MRPL47]]|0.48|
|[[:human genes:c:chchd4|CHCHD4]]|0.48|
|[[:human genes:p:pmm2|PMM2]]|0.479|
|[[:human genes:a:atp5sl|ATP5SL]]|0.478|
|[[:human genes:t:trmt61a|TRMT61A]]|0.477|
|[[:human genes:t:trmt10a|TRMT10A]]|0.477|
|[[:human genes:f:fars2|FARS2]]|0.476|
|[[:human genes:r:rpia|RPIA]]|0.476|
|[[:human genes:m:mrp63|MRP63]]|0.474|
|[[:human genes:m:mrpl12|MRPL12]]|0.474|
|[[:human genes:d:dars2|DARS2]]|0.473|
|[[:human genes:a:alg13|ALG13]]|0.473|
|[[:human genes:l:lars2|LARS2]]|0.472|
|[[:human genes:t:tmem261|TMEM261]]|0.471|
|[[:human genes:t:thg1l|THG1L]]|0.47|
|[[:human genes:m:mipep|MIPEP]]|0.47|
|[[:human genes:a:atp5h|ATP5H]]|0.47|
|[[:human genes:n:nubpl|NUBPL]]|0.469|
|[[:human genes:g:glrx5|GLRX5]]|0.469|
|[[:human genes:p:pars2|PARS2]]|0.468|
|[[:human genes:n:ndufb1|NDUFB1]]|0.465|
|[[:human genes:c:coq3|COQ3]]|0.465|
|[[:human genes:t:triap1|TRIAP1]]|0.464|
|[[:human genes:m:mto1|MTO1]]|0.464|
|[[:human genes:m:mrps24|MRPS24]]|0.463|
|[[:human genes:f:fastkd5|FASTKD5]]|0.463|
|[[:human genes:p:polg2|POLG2]]|0.462|
|[[:human genes:m:mrps11|MRPS11]]|0.461|
|[[:human genes:m:mrps9|MRPS9]]|0.46|
|[[:human genes:m:mtif3|MTIF3]]|0.46|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.459|
|[[:human genes:w:wbscr16|WBSCR16]]|0.459|
|[[:human genes:t:timm8b|TIMM8B]]|0.458|
|[[:human genes:t:trub2|TRUB2]]|0.457|
|[[:human genes:d:dap3|DAP3]]|0.457|
|[[:human genes:m:mrps18a|MRPS18A]]|0.456|
|[[:human genes:a:atxn10|ATXN10]]|0.456|
|[[:human genes:c:coq2|COQ2]]|0.455|
|[[:human genes:f:ftsj2|FTSJ2]]|0.455|
|[[:human genes:m:mtg2|MTG2]]|0.454|
|[[:human genes:u:uqcr10|UQCR10]]|0.453|
|[[:human genes:a:atp5o|ATP5O]]|0.45|
|[[:human genes:t:tomm20|TOMM20]]|0.448|
|[[:human genes:a:atp5a1|ATP5A1]]|0.446|
|[[:human genes:t:trnt1|TRNT1]]|0.445|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.445|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.443|
|[[:human genes:m:mrps2|MRPS2]]|0.443|
|[[:human genes:f:foxred1|FOXRED1]]|0.441|
|[[:human genes:m:mrps25|MRPS25]]|0.441|
|[[:human genes:d:dhrsx|DHRSX]]|0.44|
|[[:human genes:a:atp5b|ATP5B]]|0.44|
|[[:human genes:a:alas1|ALAS1]]|0.44|
|[[:human genes:m:mcat|MCAT]]|0.439|
|[[:human genes:l:lsm10|LSM10]]|0.438|
|[[:human genes:c:coq7|COQ7]]|0.438|
|[[:human genes:t:tomm40|TOMM40]]|0.436|
|[[:human genes:h:haus8|HAUS8]]|0.432|
|[[:human genes:t:tomm22|TOMM22]]|0.431|
|[[:human genes:e:elac2|ELAC2]]|0.431|
|[[:human genes:c:chchd1|CHCHD1]]|0.43|
|[[:human genes:v:vezt|VEZT]]|0.43|
|[[:human genes:a:aifm1|AIFM1]]|0.429|
|[[:human genes:a:angel2|ANGEL2]]|0.429|
|[[:human genes:u:uqcc2|UQCC2]]|0.428|
|[[:human genes:n:ndufa6|NDUFA6]]|0.427|
|[[:human genes:m:mrpl34|MRPL34]]|0.427|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.427|
|[[:human genes:a:alg8|ALG8]]|0.426|
|[[:human genes:g:gemin7|GEMIN7]]|0.426|
|[[:human genes:n:ndufb2|NDUFB2]]|0.426|
|[[:human genes:c:cox7b|COX7B]]|0.425|
|[[:human genes:p:pgm3|PGM3]]|0.425|
|[[:human genes:d:dhx30|DHX30]]|0.424|
|[[:human genes:r:rpusd3|RPUSD3]]|0.423|
|[[:human genes:a:aars2|AARS2]]|0.422|
|[[:human genes:d:dpagt1|DPAGT1]]|0.422|
|[[:human genes:m:mrpl46|MRPL46]]|0.42|
|[[:human genes:m:mrpl20|MRPL20]]|0.419|
|[[:human genes:p:pnpt1|PNPT1]]|0.418|
|[[:human genes:u:uhrf1|UHRF1]]|0.417|
|[[:human genes:m:mrps23|MRPS23]]|0.417|
|[[:human genes:a:adsl|ADSL]]|0.416|
|[[:human genes:s:slc25a19|SLC25A19]]|0.414|
|[[:human genes:i:isca2|ISCA2]]|0.414|
|[[:human genes:p:ptrhd1|PTRHD1]]|0.413|
|[[:human genes:m:mrpl11|MRPL11]]|0.413|
|[[:human genes:c:cox17|COX17]]|0.412|
|[[:human genes:u:uap1|UAP1]]|0.411|
|[[:human genes:p:ppa2|PPA2]]|0.411|
|[[:human genes:a:atp5e|ATP5E]]|0.411|
|[[:human genes:a:atp5c1|ATP5C1]]|0.411|
|[[:human genes:m:mrpl45|MRPL45]]|0.41|
|[[:human genes:r:rpe|RPE]]|0.41|
|[[:human genes:r:rars2|RARS2]]|0.408|
|[[:human genes:m:mrps17|MRPS17]]|0.408|
|[[:human genes:c:coa5|COA5]]|0.407|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.406|
|[[:human genes:a:alg6|ALG6]]|0.406|
|[[:human genes:n:ndufb7|NDUFB7]]|0.405|
|[[:human genes:p:ptdss1|PTDSS1]]|0.405|
|[[:human genes:h:hars2|HARS2]]|0.405|
|[[:human genes:m:mbtps2|MBTPS2]]|0.404|
|[[:human genes:n:nars2|NARS2]]|0.404|
|[[:human genes:n:ndufa8|NDUFA8]]|0.403|
|[[:human genes:a:alg1|ALG1]]|0.402|
|[[:human genes:m:mrpl44|MRPL44]]|0.402|
|[[:human genes:p:pet100|PET100]]|0.402|
|[[:human genes:p:ptcd1|PTCD1]]|0.401|
|[[:human genes:d:dohh|DOHH]]|0.401|
|[[:human genes:t:ten1|TEN1]]|0.401|
|[[:human genes:m:minos1|MINOS1]]|0.4|
|[[:human genes:e:eif3f|EIF3F]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|2/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4472
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C17ORF89 Expression in NALM6 Cells: 4.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>