C19orf70 [The Human Chemical-Genetic Interaction Map Project]

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======= C19orf70 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MICOS13
  * **<color #00a2e8>Official Name</color>**: mitochondrial contact site and cristae organizing system subunit 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=125988|125988]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5XKP0|Q5XKP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C19orf70&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C19orf70|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616658|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MINOS1/MIC10 into the MICOS complex. {ECO:0000269|PubMed:25997101}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial crista junction|
|MICOS complex|
|cristae formation|
|inner mitochondrial membrane organization|
|mitochondrial membrane organization|
|mitochondrial inner membrane|
|mitochondrion organization|
|membrane organization|
|mitochondrion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.11|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.88|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.83|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.75|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.73|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.7|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.81|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.84|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.92|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.93|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.27|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:minos1|MINOS1]]|0.424|
|[[:human genes:t:tmem126b|TMEM126B]]|0.422|
|[[:human genes:m:mtfmt|MTFMT]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5988
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C19ORF70 Expression in NALM6 Cells: 4.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>