C1orf131 [The Human Chemical-Genetic Interaction Map Project]

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======= C1orf131 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C1orf131
  * **<color #00a2e8>Official Name</color>**: chromosome 1 open reading frame 131
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=128061|128061]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NDD1|Q8NDD1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C1orf131&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C1orf131|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromosome|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.68|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.28|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.2|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.07|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.06|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.95|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.9|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.88|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.85|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.85|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.83|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.79|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.77|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.83|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.94|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.95|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.03|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5638
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C1orf131 Expression in NALM6 Cells: 8.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>