C1QA [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= C1QA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C1QA
  * **<color #00a2e8>Official Name</color>**: complement C1q A chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=712|712]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02745|P02745]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C1QA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C1QA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120550|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1q|
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|complement component C1 complex|
|vertebrate eye-specific patterning|
|complement-mediated synapse pruning|
|synapse pruning|
|neuron remodeling|
|astrocyte activation|
|microglial cell activation|
|leukocyte activation involved in inflammatory response|
|response to iron ion|
|astrocyte development|
|neuron maturation|
|glial cell activation|
|neuroinflammatory response|
|macrophage activation|
|astrocyte differentiation|
|collagen trimer|
|amyloid-beta binding|
|cell|
|postsynapse|
|positive regulation of neuron death|
|glial cell development|
|regulation of complement activation|
|anatomical structure maturation|
|regulation of humoral immune response|
|cell maturation|
|complement activation, classical pathway|
|humoral immune response mediated by circulating immunoglobulin|
|glial cell differentiation|
|complement activation|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|gliogenesis|
|developmental maturation|
|lymphocyte mediated immunity|
|synapse|
|synapse organization|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|aging|
|regulation of neuron death|
|regionalization|
|humoral immune response|
|visual system development|
|collagen-containing extracellular matrix|
|sensory system development|
|response to metal ion|
|cellular component disassembly|
|pattern specification process|
|regulation of immune effector process|
|inflammatory response|
|response to inorganic substance|
|myeloid leukocyte activation|
|adaptive immune response|
|activation of immune response|
|positive regulation of cell death|
|viral process|
|innate immune response|
|leukocyte mediated immunity|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|positive regulation of immune response|
|leukocyte activation|
|defense response to other organism|
|central nervous system development|
|neuron differentiation|
|cell activation|
|immune effector process|
|cell-cell signaling|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|generation of neurons|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7072
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C1QA Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>