C1R [The Human Chemical-Genetic Interaction Map Project]

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======= C1R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C1R
  * **<color #00a2e8>Official Name</color>**: complement C1r
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=715|715]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00736|P00736]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C1R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C1R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613785|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF CA|
|CUB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|zymogen activation|
|serine-type peptidase activity|
|regulation of complement activation|
|regulation of humoral immune response|
|blood microparticle|
|protein processing|
|complement activation, classical pathway|
|serine-type endopeptidase activity|
|humoral immune response mediated by circulating immunoglobulin|
|complement activation|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|protein maturation|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|humoral immune response|
|regulation of immune effector process|
|adaptive immune response|
|activation of immune response|
|calcium ion binding|
|innate immune response|
|leukocyte mediated immunity|
|positive regulation of immune response|
|defense response to other organism|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|extracellular space|
|regulation of immune system process|
|immune response|
|extracellular region|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.7|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5434
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C1R Expression in NALM6 Cells: 1.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>