C6orf106 [The Human Chemical-Genetic Interaction Map Project]

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======= C6orf106 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ILRUN
  * **<color #00a2e8>Official Name</color>**: inflammation and lipid regulator with UBA-like and NBR1-like domains
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64771|64771]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6K1|Q9H6K1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C6orf106&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C6orf106|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612217|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of defense response to virus|
|phagophore assembly site|
|negative regulation of protein localization to nucleus|
|negative regulation of type I interferon production|
|negative regulation of DNA binding|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|autophagosome|
|regulation of defense response to virus|
|ubiquitin binding|
|negative regulation of response to biotic stimulus|
|negative regulation of cellular protein localization|
|regulation of protein localization to nucleus|
|negative regulation of immune effector process|
|regulation of DNA binding|
|regulation of type I interferon production|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|macroautophagy|
|negative regulation of binding|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|autophagy|
|process utilizing autophagic mechanism|
|negative regulation of cytokine production|
|negative regulation of response to external stimulus|
|regulation of binding|
|negative regulation of immune system process|
|regulation of immune effector process|
|regulation of response to biotic stimulus|
|regulation of cellular protein localization|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of cellular localization|
|defense response to other organism|
|regulation of protein localization|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|cellular catabolic process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.97|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.9|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.89|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.75|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.8|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.11|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16169
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C6ORF106 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>