C6orf57 [The Human Chemical-Genetic Interaction Map Project]

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======= C6orf57 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDHAF4
  * **<color #00a2e8>Official Name</color>**: succinate dehydrogenase complex assembly factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=135154|135154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VUM1|Q5VUM1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C6orf57&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C6orf57|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619198|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity). {ECO:0000250|UniProtKB:P38345, ECO:0000269|PubMed:24954416}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1674|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex II assembly|
|respiratory chain complex II assembly|
|succinate dehydrogenase (ubiquinone) activity|
|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|
|neural retina development|
|mitochondrial respiratory chain complex assembly|
|retina development in camera-type eye|
|cellular respiration|
|energy derivation by oxidation of organic compounds|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular component|
|sensory organ development|
|molecular function|
|innate immune response|
|cellular protein-containing complex assembly|
|defense response to other organism|
|oxidation-reduction process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.7|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.71|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.75|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3207
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C6ORF57 Expression in NALM6 Cells: 2.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>