CACNA1I [The Human Chemical-Genetic Interaction Map Project]

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======= CACNA1I =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACNA1I
  * **<color #00a2e8>Official Name</color>**: calcium voltage-gated channel subunit alpha1 I
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8911|8911]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0X4|Q9P0X4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACNA1I&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACNA1I|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608230|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PKD channel|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|low voltage-gated calcium channel activity|
|sleep|
|positive regulation of calcium ion-dependent exocytosis|
|voltage-gated calcium channel complex|
|neuronal action potential|
|membrane depolarization during action potential|
|voltage-gated calcium channel activity|
|calcium ion import|
|regulation of calcium ion-dependent exocytosis|
|membrane depolarization|
|positive regulation of regulated secretory pathway|
|transmission of nerve impulse|
|flagellated sperm motility|
|sperm motility|
|positive regulation of exocytosis|
|cilium or flagellum-dependent cell motility|
|action potential|
|cilium-dependent cell motility|
|multicellular organismal signaling|
|regulation of regulated secretory pathway|
|calcium ion transmembrane transport|
|regulation of exocytosis|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|positive regulation of secretion by cell|
|regulation of membrane potential|
|positive regulation of secretion|
|regulation of ion transmembrane transport|
|regulation of vesicle-mediated transport|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|regulation of secretion by cell|
|regulation of secretion|
|cation transport|
|ion transmembrane transport|
|positive regulation of transport|
|localization of cell|
|cell motility|
|transmembrane transport|
|locomotion|
|ion transport|
|nervous system process|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6348
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACNA1I Expression in NALM6 Cells: -2.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>