CACNB2 [The Human Chemical-Genetic Interaction Map Project]

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======= CACNB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACNB2
  * **<color #00a2e8>Official Name</color>**: calcium voltage-gated channel auxiliary subunit beta 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=783|783]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08289|Q08289]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACNB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACNB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600003|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Guanylate kin|
|VGCC beta4Aa N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|
|voltage-gated calcium channel activity involved in AV node cell action potential|
|membrane depolarization during atrial cardiac muscle cell action potential|
|voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels|
|positive regulation of presynaptic cytosolic calcium concentration|
|induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration|
|voltage-gated calcium channel activity involved in cardiac muscle cell action potential|
|positive regulation of high voltage-gated calcium channel activity|
|membrane depolarization during AV node cell action potential|
|photoreceptor ribbon synapse|
|AV node cell to bundle of His cell signaling|
|AV node cell action potential|
|positive regulation of synaptic vesicle exocytosis|
|high voltage-gated calcium channel activity|
|AV node cell to bundle of His cell communication|
|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|
|positive regulation of voltage-gated calcium channel activity|
|L-type voltage-gated calcium channel complex|
|atrial cardiac muscle cell action potential|
|presynaptic modulation of chemical synaptic transmission|
|atrial cardiac muscle cell to AV node cell signaling|
|atrial cardiac muscle cell to AV node cell communication|
|regulation of high voltage-gated calcium channel activity|
|regulation of presynaptic cytosolic calcium ion concentration|
|membrane depolarization during cardiac muscle cell action potential|
|positive regulation of neurotransmitter secretion|
|voltage-gated calcium channel complex|
|cell-cell signaling involved in cardiac conduction|
|membrane depolarization during action potential|
|neuron cellular homeostasis|
|regulation of voltage-gated calcium channel activity|
|regulation of heart rate by cardiac conduction|
|positive regulation of neurotransmitter transport|
|cardiac muscle cell action potential involved in contraction|
|positive regulation of calcium ion transmembrane transporter activity|
|voltage-gated calcium channel activity|
|cardiac muscle cell contraction|
|neuromuscular junction development|
|calcium ion import|
|cell communication involved in cardiac conduction|
|cardiac muscle cell action potential|
|membrane depolarization|
|positive regulation of regulated secretory pathway|
|calcium channel activity|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|cardiac muscle contraction|
|regulation of synaptic vesicle exocytosis|
|heart contraction|
|regulation of calcium ion transmembrane transporter activity|
|positive regulation of exocytosis|
|actin-mediated cell contraction|
|cardiac conduction|
|presynapse|
|action potential|
|regulation of heart rate|
|heart process|
|positive regulation of ion transmembrane transporter activity|
|regulation of neurotransmitter secretion|
|striated muscle contraction|
|actin filament-based movement|
|positive regulation of transporter activity|
|regulation of synaptic vesicle cycle|
|positive regulation of calcium ion transport|
|multicellular organismal signaling|
|positive regulation of cation transmembrane transport|
|regulation of neurotransmitter transport|
|regulation of calcium ion transmembrane transport|
|positive regulation of synaptic transmission|
|positive regulation of ion transmembrane transport|
|regulation of regulated secretory pathway|
|regulation of cation channel activity|
|protein localization to plasma membrane|
|calcium ion transmembrane transport|
|positive regulation of transmembrane transport|
|actin filament binding|
|visual perception|
|regulation of exocytosis|
|sensory perception of light stimulus|
|protein localization to cell periphery|
|regulation of heart contraction|
|regulation of calcium ion transport|
|calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|synapse organization|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|anatomical structure homeostasis|
|regulation of neurotransmitter levels|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|divalent inorganic cation homeostasis|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|sensory perception|
|positive regulation of transport|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.8|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.07|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11874
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACNB2 Expression in NALM6 Cells: 4.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>