CACNB3 [The Human Chemical-Genetic Interaction Map Project]

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======= CACNB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACNB3
  * **<color #00a2e8>Official Name</color>**: calcium voltage-gated channel auxiliary subunit beta 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=784|784]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54284|P54284]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACNB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACNB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601958|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VGCC beta4Aa N|
|Guanylate kin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of detection of mechanical stimulus involved in sensory perception of touch|
|negative regulation of detection of mechanical stimulus involved in sensory perception of touch|
|regulation of membrane hyperpolarization|
|calcium ion transmembrane transport via high voltage-gated calcium channel|
|positive regulation of high voltage-gated calcium channel activity|
|regulation of membrane repolarization during action potential|
|response to oxygen-glucose deprivation|
|cellular response to oxygen-glucose deprivation|
|high voltage-gated calcium channel activity|
|positive regulation of voltage-gated calcium channel activity|
|L-type voltage-gated calcium channel complex|
|detection of mechanical stimulus involved in sensory perception of pain|
|negative regulation of voltage-gated calcium channel activity|
|regulation of high voltage-gated calcium channel activity|
|negative regulation of nervous system process|
|voltage-gated calcium channel complex|
|positive regulation of excitatory postsynaptic potential|
|detection of mechanical stimulus involved in sensory perception|
|positive regulation of protein targeting to membrane|
|regulation of membrane repolarization|
|regulation of voltage-gated calcium channel activity|
|negative regulation of calcium ion transmembrane transporter activity|
|regulation of protein targeting to membrane|
|calcium channel regulator activity|
|positive regulation of calcium ion transmembrane transporter activity|
|negative regulation of calcium ion transmembrane transport|
|modulation of excitatory postsynaptic potential|
|regulation of sensory perception|
|voltage-gated calcium channel activity|
|neuromuscular junction development|
|negative regulation of cation channel activity|
|detection of mechanical stimulus|
|regulation of action potential|
|membrane depolarization|
|negative regulation of calcium ion transport|
|positive regulation of nervous system process|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|calcium ion transport into cytosol|
|sensory perception of pain|
|negative regulation of transporter activity|
|regulation of protein targeting|
|negative regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transporter activity|
|cytosolic calcium ion transport|
|cardiac conduction|
|negative regulation of ion transmembrane transport|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|detection of external stimulus|
|positive regulation of calcium ion transport|
|detection of abiotic stimulus|
|positive regulation of protein localization to membrane|
|multicellular organismal signaling|
|regulation of nervous system process|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|positive regulation of synaptic transmission|
|positive regulation of intracellular protein transport|
|positive regulation of ion transmembrane transport|
|sensory perception of mechanical stimulus|
|regulation of cation channel activity|
|T cell receptor signaling pathway|
|protein localization to plasma membrane|
|regulation of protein localization to membrane|
|cellular response to decreased oxygen levels|
|calcium ion transmembrane transport|
|positive regulation of transmembrane transport|
|positive regulation of intracellular transport|
|response to mechanical stimulus|
|cellular response to oxygen levels|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|cellular response to nutrient levels|
|regulation of heart contraction|
|regulation of calcium ion transport|
|calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|cellular response to extracellular stimulus|
|synapse organization|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|antigen receptor-mediated signaling pathway|
|divalent metal ion transport|
|divalent inorganic cation transport|
|apical plasma membrane|
|positive regulation of cellular protein localization|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|cellular response to external stimulus|
|regulation of intracellular transport|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|response to oxygen levels|
|regulation of metal ion transport|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|positive regulation of protein transport|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of cellular protein localization|
|detection of stimulus involved in sensory perception|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|regulation of system process|
|immune response-regulating signaling pathway|
|cation transmembrane transport|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|detection of stimulus|
|regulation of ion transport|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|ion homeostasis|
|cation transport|
|positive regulation of immune response|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|sensory perception|
|positive regulation of transport|
|regulation of protein localization|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|transmembrane transport|
|ion transport|
|nervous system process|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.76|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 17/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|2/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8377
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACNB3 Expression in NALM6 Cells: 4.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>