CADPS [The Human Chemical-Genetic Interaction Map Project]

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======= CADPS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CADPS
  * **<color #00a2e8>Official Name</color>**: calcium dependent secretion activator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8618|8618]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULU8|Q9ULU8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CADPS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CADPS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604667|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1041|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dense core granule exocytosis|
|calcium-ion regulated exocytosis|
|synaptic vesicle exocytosis|
|positive regulation of exocytosis|
|presynapse|
|signal release from synapse|
|neurotransmitter secretion|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|cytoplasmic vesicle membrane|
|lipid binding|
|signal release|
|neurotransmitter transport|
|regulation of exocytosis|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of secretion by cell|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of secretion|
|trans-synaptic signaling|
|synaptic signaling|
|protein kinase binding|
|cell junction|
|regulation of vesicle-mediated transport|
|regulated exocytosis|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|positive regulation of transport|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.28|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.19|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.17|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.89|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.87|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.87|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.84|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.83|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.72|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.71|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.71|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.78|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.8|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.84|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.89|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.95|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.02|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.12|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.23|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5478
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CADPS Expression in NALM6 Cells: 1.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>