CALCOCO2 [The Human Chemical-Genetic Interaction Map Project]

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======= CALCOCO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CALCOCO2
  * **<color #00a2e8>Official Name</color>**: calcium binding and coiled-coil domain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10241|10241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13137|Q13137]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CALCOCO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CALCOCO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604587|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CALCOCO1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|xenophagy|
|positive regulation of autophagosome maturation|
|regulation of autophagosome maturation|
|selective autophagy|
|autophagosome membrane|
|positive regulation of protein complex disassembly|
|positive regulation of macroautophagy|
|autophagosome|
|regulation of protein complex disassembly|
|positive regulation of autophagy|
|macroautophagy|
|regulation of macroautophagy|
|response to interferon-gamma|
|cytoplasmic vesicle|
|process utilizing autophagic mechanism|
|autophagy|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|cytoskeleton|
|positive regulation of catabolic process|
|positive regulation of organelle organization|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|viral process|
|innate immune response|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|defense response to other organism|
|regulation of catabolic process|
|response to cytokine|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|cellular catabolic process|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.9|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.83|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.71|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.75|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.76|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.14|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13316
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CALCOCO2 Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>