CAMK2D [The Human Chemical-Genetic Interaction Map Project]

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======= CAMK2D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAMK2D
  * **<color #00a2e8>Official Name</color>**: calcium/calmodulin dependent protein kinase II delta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=817|817]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13557|Q13557]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAMK2D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAMK2D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607708|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser- 2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor- coupling factor. {ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|CaMKII AD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of relaxation of cardiac muscle|
|sodium channel inhibitor activity|
|regulation of cardiac muscle cell action potential involved in regulation of contraction|
|regulation of histone deacetylase activity|
|regulation of cell communication by electrical coupling involved in cardiac conduction|
|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|
|regulation of relaxation of muscle|
|regulation of deacetylase activity|
|regulation of cell communication by electrical coupling|
|negative regulation of sodium ion transmembrane transporter activity|
|relaxation of cardiac muscle|
|positive regulation of cardiac muscle cell apoptotic process|
|positive regulation of striated muscle cell apoptotic process|
|negative regulation of sodium ion transmembrane transport|
|titin binding|
|negative regulation of sodium ion transport|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|relaxation of muscle|
|endoplasmic reticulum calcium ion homeostasis|
|calmodulin-dependent protein kinase activity|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of the force of heart contraction|
|regulation of cardiac muscle cell action potential|
|regulation of histone deacetylation|
|positive regulation of muscle cell apoptotic process|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|positive regulation of cardiac muscle hypertrophy|
|sarcoplasmic reticulum membrane|
|positive regulation of muscle hypertrophy|
|regulation of cardiac muscle cell apoptotic process|
|regulation of cardiac muscle cell contraction|
|regulation of heart rate by cardiac conduction|
|regulation of striated muscle cell apoptotic process|
|regulation of actin filament-based movement|
|cardiac muscle cell contraction|
|regulation of protein deacetylation|
|regulation of membrane depolarization|
|regulation of action potential|
|regulation of sodium ion transmembrane transporter activity|
|regulation of cardiac muscle hypertrophy|
|regulation of muscle hypertrophy|
|regulation of sodium ion transmembrane transport|
|regulation of muscle cell apoptotic process|
|endocytic vesicle membrane|
|regulation of cardiac conduction|
|negative regulation of ion transmembrane transporter activity|
|interferon-gamma-mediated signaling pathway|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|cardiac muscle contraction|
|regulation of cellular response to heat|
|negative regulation of transporter activity|
|peptidyl-threonine phosphorylation|
|negative regulation of cation transmembrane transport|
|cellular response to calcium ion|
|regulation of muscle adaptation|
|regulation of sodium ion transport|
|heart contraction|
|regulation of calcium ion transmembrane transporter activity|
|actin-mediated cell contraction|
|peptidyl-threonine modification|
|regulation of striated muscle contraction|
|cardiac conduction|
|negative regulation of ion transmembrane transport|
|regulation of heart rate|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|sarcolemma|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|negative regulation of transmembrane transport|
|regulation of sequestering of calcium ion|
|ion channel binding|
|multicellular organismal signaling|
|regulation of histone modification|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|response to calcium ion|
|regulation of muscle contraction|
|cellular response to interferon-gamma|
|regulation of cation channel activity|
|peptidyl-serine phosphorylation|
|response to interferon-gamma|
|regulation of chromatin organization|
|cellular response to metal ion|
|protein autophosphorylation|
|peptidyl-serine modification|
|calmodulin binding|
|cellular response to inorganic substance|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|regulation of blood circulation|
|muscle system process|
|neuron projection|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|regulation of chromosome organization|
|protein serine/threonine kinase activity|
|response to metal ion|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|regulation of cell growth|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|protein complex oligomerization|
|response to inorganic substance|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|regulation of growth|
|cytokine-mediated signaling pathway|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|innate immune response|
|ion homeostasis|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|cellular homeostasis|
|regulation of cellular localization|
|defense response to other organism|
|protein phosphorylation|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|identical protein binding|
|response to cytokine|
|chemical homeostasis|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|homeostatic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.91|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.77|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18856
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAMK2D Expression in NALM6 Cells: 0.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>