CAMK2G [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CAMK2G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAMK2G
  * **<color #00a2e8>Official Name</color>**: calcium/calmodulin dependent protein kinase II gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=818|818]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13555|Q13555]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAMK2G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAMK2G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602123|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|CaMKII AD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent protein serine/threonine phosphatase activity|
|regulation of skeletal muscle adaptation|
|calmodulin-dependent protein kinase activity|
|sarcoplasmic reticulum membrane|
|insulin secretion|
|peptide hormone secretion|
|endocytic vesicle membrane|
|hormone secretion|
|interferon-gamma-mediated signaling pathway|
|regulation of cellular response to heat|
|hormone transport|
|regulation of muscle adaptation|
|protein secretion|
|establishment of protein localization to extracellular region|
|cellular response to interferon-gamma|
|protein localization to extracellular region|
|signal release|
|peptide secretion|
|response to interferon-gamma|
|calmodulin binding|
|protein dephosphorylation|
|regulation of muscle system process|
|regulation of calcium ion transport|
|dephosphorylation|
|neuron projection|
|regulation of metal ion transport|
|protein complex oligomerization|
|regulation of hormone levels|
|regulation of system process|
|cytokine-mediated signaling pathway|
|regulation of ion transport|
|regulation of cellular response to stress|
|innate immune response|
|protein homodimerization activity|
|defense response to other organism|
|protein phosphorylation|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|identical protein binding|
|response to cytokine|
|cell-cell signaling|
|secretion|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|ATP binding|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.26|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.24|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.09|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.07|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.87|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.79|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.72|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.74|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.76|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.9|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.94|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.97|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.05|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kctd5|KCTD5]]|0.411|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13778
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAMK2G Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>