CAMSAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= CAMSAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAMSAP1
  * **<color #00a2e8>Official Name</color>**: calmodulin regulated spectrin associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=157922|157922]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T5Y3|Q5T5Y3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAMSAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAMSAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613774|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAMSAP CKK|
|CAMSAP CH|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule minus-end|
|microtubule minus-end binding|
|negative regulation of microtubule depolymerization|
|spectrin binding|
|regulation of microtubule depolymerization|
|negative regulation of microtubule polymerization or depolymerization|
|regulation of microtubule polymerization|
|cytoplasmic microtubule organization|
|negative regulation of protein depolymerization|
|negative regulation of protein complex disassembly|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|regulation of protein complex disassembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|regulation of microtubule cytoskeleton organization|
|calmodulin binding|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|microtubule binding|
|microtubule|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|regulation of cell morphogenesis|
|regulation of cytoskeleton organization|
|neuron projection development|
|microtubule-based process|
|negative regulation of cellular component organization|
|neuron development|
|regulation of cellular component biogenesis|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|generation of neurons|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.74|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.84|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.88|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.16|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6280
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAMSAP1 Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>