CARTPT [The Human Chemical-Genetic Interaction Map Project]

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======= CARTPT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CARTPT
  * **<color #00a2e8>Official Name</color>**: CART prepropeptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9607|9607]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16568|Q16568]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CARTPT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CARTPT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602606|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro. {ECO:0000269|PubMed:9590691}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CART|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of epinephrine secretion|
|somatostatin secretion|
|negative regulation of glucagon secretion|
|positive regulation of transmission of nerve impulse|
|regulation of epinephrine secretion|
|regulation of glucagon secretion|
|adult feeding behavior|
|negative regulation of response to food|
|positive regulation of catecholamine secretion|
|negative regulation of bone resorption|
|negative regulation of appetite|
|negative regulation of response to nutrient levels|
|negative regulation of bone remodeling|
|negative regulation of response to extracellular stimulus|
|regulation of transmission of nerve impulse|
|regulation of response to food|
|negative regulation of tissue remodeling|
|regulation of appetite|
|regulation of response to extracellular stimulus|
|regulation of response to nutrient levels|
|negative regulation of osteoclast differentiation|
|neuropeptide hormone activity|
|positive regulation of amine transport|
|positive regulation of blood pressure|
|regulation of bone resorption|
|negative regulation of peptide hormone secretion|
|negative regulation of myeloid leukocyte differentiation|
|regulation of bone remodeling|
|activation of MAPKK activity|
|peptide hormone secretion|
|regulation of catecholamine secretion|
|circadian regulation of gene expression|
|positive regulation of nervous system process|
|negative regulation of hormone secretion|
|regulation of osteoclast differentiation|
|hormone secretion|
|regulation of tissue remodeling|
|negative regulation of myeloid cell differentiation|
|hormone transport|
|feeding behavior|
|secretory granule|
|cellular glucose homeostasis|
|regulation of amine transport|
|negative regulation of leukocyte differentiation|
|neuropeptide signaling pathway|
|regulation of myeloid leukocyte differentiation|
|regulation of nervous system process|
|negative regulation of hemopoiesis|
|negative regulation of peptide secretion|
|circadian rhythm|
|adult behavior|
|cellular response to starvation|
|signal release|
|peptide secretion|
|regulation of insulin secretion|
|regulation of blood pressure|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to starvation|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|regulation of myeloid cell differentiation|
|negative regulation of secretion|
|cellular response to nutrient levels|
|positive regulation of MAP kinase activity|
|cellular response to extracellular stimulus|
|regulation of hormone secretion|
|regulation of leukocyte differentiation|
|rhythmic process|
|activation of protein kinase activity|
|cellular response to external stimulus|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|negative regulation of response to external stimulus|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of secretion|
|trans-synaptic signaling|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|synaptic signaling|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|response to nutrient levels|
|regulation of protein serine/threonine kinase activity|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of MAPK cascade|
|behavior|
|positive regulation of kinase activity|
|regulation of system process|
|positive regulation of transferase activity|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|molecular function|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of kinase activity|
|cellular homeostasis|
|negative regulation of developmental process|
|regulation of transferase activity|
|positive regulation of transport|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|peptide transport|
|amide transport|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4542
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CARTPT Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>