CATSPER4 [The Human Chemical-Genetic Interaction Map Project]

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======= CATSPER4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CATSPER4
  * **<color #00a2e8>Official Name</color>**: cation channel sperm associated 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=378807|378807]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7RTX7|Q7RTX7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CATSPER4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CATSPER4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609121|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PKD channel|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CatSper complex|
|calcium activated cation channel activity|
|sperm principal piece|
|sperm capacitation|
|voltage-gated calcium channel activity|
|response to progesterone|
|sperm-egg recognition|
|cell-cell recognition|
|sperm motility|
|flagellated sperm motility|
|acrosomal vesicle|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|single fertilization|
|spermatid development|
|sodium ion transport|
|spermatid differentiation|
|cell maturation|
|fertilization|
|response to ketone|
|calcium ion transmembrane transport|
|cell recognition|
|developmental maturation|
|calcium ion transport|
|germ cell development|
|divalent metal ion transport|
|divalent inorganic cation transport|
|response to steroid hormone|
|cellular process involved in reproduction in multicellular organism|
|monovalent inorganic cation transport|
|regulation of ion transmembrane transport|
|spermatogenesis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|male gamete generation|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|developmental process involved in reproduction|
|gamete generation|
|regulation of ion transport|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|ion transmembrane transport|
|multi-organism reproductive process|
|response to drug|
|cell motility|
|localization of cell|
|transmembrane transport|
|locomotion|
|ion transport|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|cell development|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.73|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.74|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8759
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CATSPER4 Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>