CBLL1 [The Human Chemical-Genetic Interaction Map Project]

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======= CBLL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CBLL1
  * **<color #00a2e8>Official Name</color>**: Cbl proto-oncogene like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79872|79872]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q75N03|Q75N03]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CBLL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CBLL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606872|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes ubiquitination of several tyrosine- phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|entry of bacterium into host cell|
|RNA N6-methyladenosine methyltransferase complex|
|mRNA methylation|
|mRNA modification|
|RNA methylation|
|positive regulation of endocytosis|
|entry into host cell|
|entry into host|
|ubiquitin ligase complex|
|interaction with host|
|RNA modification|
|regulation of endocytosis|
|ubiquitin protein ligase activity|
|ubiquitin-protein transferase activity|
|macromolecule methylation|
|negative regulation of cell adhesion|
|methylation|
|nuclear speck|
|positive regulation of cell migration|
|cell-cell adhesion|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|regulation of cell adhesion|
|protein ubiquitination|
|mRNA metabolic process|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of cellular component movement|
|identical protein binding|
|positive regulation of cellular component organization|
|RNA metabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.75|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.75|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.74|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.82|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.03|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.04|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.13|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.24|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.26|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.42|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.83|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.87|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.19|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mettl14|METTL14]]|0.475|
|[[:human genes:y:ythdf2|YTHDF2]]|0.471|
|[[:human genes:c:cxorf56|CXorf56]]|0.465|
|[[:human genes:d:dazap1|DAZAP1]]|0.415|
|[[:human genes:r:rbm26|RBM26]]|0.413|
|[[:human genes:d:dph1|DPH1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 21/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|2/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3958
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CBLL1 Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>