CCAR1 [The Human Chemical-Genetic Interaction Map Project]

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======= CCAR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCAR1
  * **<color #00a2e8>Official Name</color>**: cell division cycle and apoptosis regulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55749|55749]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IX12|Q8IX12]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCAR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCAR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612569|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear receptor transcription coactivator activity|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|transcription corepressor activity|
|transcription coactivator activity|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|mRNA metabolic process|
|perinuclear region of cytoplasm|
|regulation of cell migration|
|RNA processing|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|regulation of locomotion|
|regulation of cellular component movement|
|programmed cell death|
|cell death|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.16|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.15|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.1|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.83|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.82|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.82|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.79|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.75|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.85|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.99|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|4.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.442|
|[[:human genes:e:eif4a2|EIF4A2]]|0.418|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 182/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|7/28|
|bone|5/25|
|breast|6/33|
|central nervous system|9/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|3/15|
|kidney|4/21|
|liver|8/20|
|lung|21/75|
|lymphocyte|1/14|
|ovary|8/26|
|pancreas|6/24|
|peripheral nervous system|8/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|2/7|
|thyroid|0/2|
|upper aerodigestive|11/22|
|urinary tract|10/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1565
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCAR1 Expression in NALM6 Cells: 8.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>