CCDC115 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC115 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC115
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 115
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84317|84317]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96NT0|Q96NT0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC115&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC115|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) vesicles in some human cells. The encoded protein shares some homology with the yeast V-ATPase assembly factor Vma22p, and the orthologous protein in mouse promotes cell proliferation and suppresses cell death. Defects in this gene are a cause of congenital disorder of glycosylation, type IIo in humans. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833332). {ECO:0000269|PubMed:26833332, ECO:0000269|PubMed:28296633}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysosomal protein catabolic process|
|protein catabolic process in the vacuole|
|vacuolar proton-transporting V-type ATPase complex assembly|
|proton-transporting V-type ATPase complex assembly|
|extrinsic component of endoplasmic reticulum membrane|
|COPI-coated vesicle|
|lysosomal lumen acidification|
|regulation of lysosomal lumen pH|
|proton-transporting two-sector ATPase complex assembly|
|vacuolar proton-transporting V-type ATPase complex|
|cellular response to increased oxygen levels|
|vacuolar acidification|
|response to increased oxygen levels|
|intracellular pH reduction|
|pH reduction|
|lytic vacuole organization|
|lysosome organization|
|cellular iron ion homeostasis|
|endoplasmic reticulum-Golgi intermediate compartment|
|iron ion homeostasis|
|regulation of intracellular pH|
|regulation of cellular pH|
|regulation of pH|
|cellular transition metal ion homeostasis|
|cellular monovalent inorganic cation homeostasis|
|vacuole organization|
|transition metal ion homeostasis|
|unfolded protein binding|
|monovalent inorganic cation homeostasis|
|cellular response to oxygen levels|
|lysosome|
|endosome|
|response to oxygen levels|
|cellular metal ion homeostasis|
|cellular protein catabolic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|protein catabolic process|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular protein-containing complex assembly|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chemical homeostasis|
|response to abiotic stimulus|
|protein-containing complex assembly|
|homeostatic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.95|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.89|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gtf3c4|GTF3C4]]|0.5|
|[[:human genes:c:cdipt|CDIPT]]|0.473|
|[[:human genes:d:dolk|DOLK]]|0.467|
|[[:human genes:v:vma21|VMA21]]|0.465|
|[[:human genes:p:ppp4c|PPP4C]]|0.454|
|[[:human genes:r:rabggtb|RABGGTB]]|0.443|
|[[:human genes:t:timm22|TIMM22]]|0.429|
|[[:human genes:e:exoc3|EXOC3]]|0.418|
|[[:human genes:f:fen1|FEN1]]|0.418|
|[[:human genes:d:dpagt1|DPAGT1]]|0.416|
|[[:human genes:a:alg1|ALG1]]|0.408|
|[[:human genes:c:ciao1|CIAO1]]|0.406|
|[[:human genes:r:rtcb|RTCB]]|0.402|
|[[:human genes:b:bub3|BUB3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 484/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|20/28|
|bone|17/26|
|breast|20/33|
|central nervous system|39/56|
|cervix|2/4|
|colorectal|8/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|17/21|
|liver|12/20|
|lung|41/75|
|lymphocyte|6/16|
|ovary|10/26|
|pancreas|14/24|
|peripheral nervous system|5/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|20/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|24/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1366
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC115 Expression in NALM6 Cells: 4.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>