CCDC130 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC130 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC130
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 130
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81576|81576]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13994|P13994]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC130&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC130|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF572|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to virus|
|cellular component|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.78|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.6|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.83|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.79|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.76|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.88|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:itfg2|ITFG2]]|0.486|
|[[:human genes:n:nprl2|NPRL2]]|0.485|
|[[:human genes:c:c12orf66|C12orf66]]|0.485|
|[[:human genes:n:nprl3|NPRL3]]|0.473|
|[[:human genes:s:szt2|SZT2]]|0.469|
|[[:human genes:d:depdc5|DEPDC5]]|0.454|
|[[:human genes:a:arid4b|ARID4B]]|0.429|
|[[:human genes:s:sesn2|SESN2]]|0.422|
|[[:human genes:k:kptn|KPTN]]|0.415|
|[[:human genes:w:wdr83|WDR83]]|0.413|
|[[:human genes:p:pds5b|PDS5B]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 281/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|11/28|
|blood|5/28|
|bone|8/26|
|breast|21/33|
|central nervous system|10/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|8/21|
|liver|5/20|
|lung|36/75|
|lymphocyte|9/16|
|ovary|12/26|
|pancreas|15/24|
|peripheral nervous system|5/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|17/22|
|urinary tract|12/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2146
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC130 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>