CCDC22 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC22
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28952|28952]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60826|O60826]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300859|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF- kappa-B activity via association with COMMD1 and involving a CUL2- dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). {ECO:0000269|PubMed:23563313, ECO:0000269|PubMed:25355947}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF812|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic sequestering of NF-kappaB|
|cellular copper ion homeostasis|
|cytoplasmic sequestering of transcription factor|
|copper ion homeostasis|
|cullin family protein binding|
|cytoplasmic sequestering of protein|
|retrograde transport, endosome to plasma membrane|
|endocytic recycling|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|Golgi to plasma membrane transport|
|negative regulation of NF-kappaB transcription factor activity|
|vesicle-mediated transport to the plasma membrane|
|positive regulation of ubiquitin-dependent protein catabolic process|
|post-Golgi vesicle-mediated transport|
|maintenance of protein location|
|cellular transition metal ion homeostasis|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|transition metal ion homeostasis|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of DNA-binding transcription factor activity|
|maintenance of location|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|endosomal transport|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of cellular protein catabolic process|
|endosome|
|positive regulation of proteolysis|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|Golgi vesicle transport|
|regulation of protein catabolic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|cellular component|
|negative regulation of intracellular signal transduction|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|protein ubiquitination|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|cellular chemical homeostasis|
|protein modification by small protein conjugation|
|ion homeostasis|
|regulation of cellular catabolic process|
|cellular homeostasis|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|positive regulation of intracellular signal transduction|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.94|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.82|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.8|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.74|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.69|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.64|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.51|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.5|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.48|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.4|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.28|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.14|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.13|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.1|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.02|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.96|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.86|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.83|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.74|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.71|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.75|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:commd5|COMMD5]]|0.688|
|[[:human genes:c:commd3|COMMD3]]|0.588|
|[[:human genes:v:vps29|VPS29]]|0.586|
|[[:human genes:k:kiaa0196|KIAA0196]]|0.571|
|[[:human genes:a:arpc4|ARPC4]]|0.569|
|[[:human genes:a:arpc2|ARPC2]]|0.562|
|[[:human genes:c:commd10|COMMD10]]|0.538|
|[[:human genes:c:ccdc53|CCDC53]]|0.534|
|[[:human genes:a:actr3|ACTR3]]|0.531|
|[[:human genes:c:commd9|COMMD9]]|0.511|
|[[:human genes:r:rab7a|RAB7A]]|0.51|
|[[:human genes:k:kiaa1033|KIAA1033]]|0.49|
|[[:human genes:v:vps35|VPS35]]|0.474|
|[[:human genes:c:commd2|COMMD2]]|0.472|
|[[:human genes:a:actr2|ACTR2]]|0.455|
|[[:human genes:c:commd7|COMMD7]]|0.436|
|[[:human genes:c:c16orf62|C16orf62]]|0.435|
|[[:human genes:v:vps45|VPS45]]|0.423|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|1/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|2/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5414
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC22 Expression in NALM6 Cells: 4.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>