CCDC39 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC39 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC39
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 39
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=339829|339829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UFE4|Q9UFE4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC39&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC39|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613798|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in the motility of cilia and flagella. The encoded protein is essential for the assembly of dynein regulatory and inner dynein arm complexes, which regulate ciliary beat. Defects in this gene are a cause of primary ciliary dyskinesia type 14 (CILD14). [provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972). Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (PubMed:21131972). {ECO:0000250|UniProtKB:A8IQT2, ECO:0000269|PubMed:21131972}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of left/right asymmetry|
|cerebrospinal fluid circulation|
|determination of pancreatic left/right asymmetry|
|determination of liver left/right asymmetry|
|determination of digestive tract left/right asymmetry|
|epithelial cilium movement involved in determination of left/right asymmetry|
|regulation of cilium beat frequency|
|inner dynein arm assembly|
|regulation of cilium movement|
|motile cilium assembly|
|epithelial cilium movement involved in extracellular fluid movement|
|extracellular transport|
|regulation of microtubule-based movement|
|axonemal dynein complex assembly|
|protein localization to cilium|
|cilium movement|
|heart looping|
|axoneme assembly|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|sperm motility|
|flagellated sperm motility|
|pancreas development|
|embryonic heart tube development|
|microtubule bundle formation|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|axoneme|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|liver development|
|hepaticobiliary system development|
|digestive tract development|
|digestive system development|
|lung development|
|respiratory tube development|
|microtubule-based transport|
|respiratory system development|
|cilium|
|regulation of microtubule-based process|
|heart morphogenesis|
|microtubule-based movement|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|cilium assembly|
|cilium organization|
|gland development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|microtubule cytoskeleton organization|
|heart development|
|tissue morphogenesis|
|embryonic morphogenesis|
|tube morphogenesis|
|microtubule-based process|
|protein localization to organelle|
|brain development|
|organelle assembly|
|head development|
|cellular protein-containing complex assembly|
|tube development|
|circulatory system development|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|regulation of cellular component movement|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|nervous system process|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|tissue development|
|protein-containing complex subunit organization|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.7|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14245
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC39 Expression in NALM6 Cells: 3.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>