CCDC47 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC47 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC47
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 47
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57003|57003]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A33|Q96A33]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC47&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC47|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618260|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1682|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ER overload response|
|ER-nucleus signaling pathway|
|endoplasmic reticulum organization|
|rough endoplasmic reticulum|
|ubiquitin-dependent ERAD pathway|
|post-embryonic development|
|ERAD pathway|
|osteoblast differentiation|
|cellular response to biotic stimulus|
|response to endoplasmic reticulum stress|
|ossification|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|endomembrane system organization|
|calcium ion homeostasis|
|divalent inorganic cation homeostasis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|metal ion homeostasis|
|protein catabolic process|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|ion homeostasis|
|cellular macromolecule catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|chemical homeostasis|
|proteolysis|
|response to biotic stimulus|
|RNA binding|
|homeostatic process|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.73|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.33|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.23|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.11|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.02|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.01|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.99|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.94|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.91|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.88|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.84|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.77|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.72|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.72|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.72|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.74|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.75|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.79|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.9|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.02|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.15|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c20orf24|C20orf24]]|0.498|
|[[:human genes:t:tmem147|TMEM147]]|0.484|
|[[:human genes:v:vps35|VPS35]]|0.415|
|[[:human genes:n:ncln|NCLN]]|0.409|
|[[:human genes:w:wdr83os|WDR83OS]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10872
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC47 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>