CCDC93 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC93 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC93
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 93
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54520|54520]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q567U6|Q567U6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC93&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC93|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620553|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947). {ECO:0000269|PubMed:25355947}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KOG2701|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retrograde transport, endosome to plasma membrane|
|endocytic recycling|
|Golgi to plasma membrane transport|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|endosomal transport|
|early endosome|
|Golgi vesicle transport|
|intracellular membrane-bounded organelle|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.19|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.8|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.79|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:commd3|COMMD3]]|0.408|
|[[:human genes:v:vps29|VPS29]]|0.407|
|[[:human genes:c:commd4|COMMD4]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2436
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC93 Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>