CCL16 [The Human Chemical-Genetic Interaction Map Project]

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======= CCL16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCL16
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine ligand 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6360|6360]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15467|O15467]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCL16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCL16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601394|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eosinophil chemotaxis|
|eosinophil migration|
|CCR chemokine receptor binding|
|chemoattractant activity|
|monocyte chemotaxis|
|lymphocyte chemotaxis|
|mononuclear cell migration|
|positive chemotaxis|
|chemokine activity|
|lymphocyte migration|
|chemokine-mediated signaling pathway|
|neutrophil chemotaxis|
|granulocyte chemotaxis|
|response to chemokine|
|cellular response to chemokine|
|neutrophil migration|
|granulocyte migration|
|myeloid leukocyte migration|
|leukocyte chemotaxis|
|cellular response to interferon-gamma|
|cellular response to interleukin-1|
|response to interferon-gamma|
|response to interleukin-1|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|regulation of ERK1 and ERK2 cascade|
|leukocyte migration|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|inflammatory response|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cytokine-mediated signaling pathway|
|regulation of MAPK cascade|
|innate immune response|
|positive regulation of hydrolase activity|
|defense response to other organism|
|cell migration|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.42|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.17|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2.13|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.01|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.9|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.8|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.78|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.76|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.72|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.85|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.98|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.04|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.11|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.428|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16546
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCL16 Expression in NALM6 Cells: 3.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>