CCL20 [The Human Chemical-Genetic Interaction Map Project]

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======= CCL20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCL20
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine ligand 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6364|6364]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78556|P78556]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCL20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCL20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601960|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B- cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255). {ECO:0000250|UniProtKB:O89093, ECO:0000269|PubMed:11035086, ECO:0000269|PubMed:11352563, ECO:0000269|PubMed:12149255, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:9038201, ECO:0000269|PubMed:9129037, ECO:0000303|PubMed:21376174}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thymocyte migration|
|CCR6 chemokine receptor binding|
|calcium-mediated signaling using intracellular calcium source|
|T cell migration|
|CCR chemokine receptor binding|
|positive regulation of T cell migration|
|positive regulation of lymphocyte migration|
|monocyte chemotaxis|
|regulation of T cell migration|
|lymphocyte chemotaxis|
|mononuclear cell migration|
|chemokine activity|
|regulation of lymphocyte migration|
|lymphocyte migration|
|chemokine-mediated signaling pathway|
|neutrophil chemotaxis|
|granulocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|neutrophil migration|
|granulocyte migration|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|cellular response to interferon-gamma|
|cellular response to interleukin-1|
|response to interferon-gamma|
|regulation of leukocyte migration|
|response to interleukin-1|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|regulation of ERK1 and ERK2 cascade|
|defense response to bacterium|
|second-messenger-mediated signaling|
|leukocyte migration|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|inflammatory response|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of MAPK cascade|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|regulation of cell motility|
|defense response to other organism|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.01|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18869
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCL20 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>