CCL5 [The Human Chemical-Genetic Interaction Map Project]

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======= CCL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCL5
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine ligand 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6352|6352]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13501|P13501]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/187011|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1- infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1- 68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485). {ECO:0000269|PubMed:1380064, ECO:0000269|PubMed:15923218, ECO:0000269|PubMed:16791620, ECO:0000269|PubMed:17001303, ECO:0000269|PubMed:23979485, ECO:0000269|PubMed:8525373, ECO:0000269|PubMed:9516414}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chemokine receptor antagonist activity|
|CCR4 chemokine receptor binding|
|receptor signaling protein tyrosine kinase activator activity|
|CCR1 chemokine receptor binding|
|activation of phospholipase D activity|
|positive regulation of natural killer cell chemotaxis|
|positive regulation of homotypic cell-cell adhesion|
|negative regulation of macrophage apoptotic process|
|positive regulation of cell-cell adhesion mediated by integrin|
|negative regulation of chemokine-mediated signaling pathway|
|CCR5 chemokine receptor binding|
|positive regulation of activation of Janus kinase activity|
|phospholipase activator activity|
|chemokine receptor binding|
|regulation of natural killer cell chemotaxis|
|regulation of activation of Janus kinase activity|
|regulation of chronic inflammatory response|
|regulation of chemokine-mediated signaling pathway|
|regulation of macrophage apoptotic process|
|regulation of cell-cell adhesion mediated by integrin|
|positive regulation of T cell apoptotic process|
|macrophage chemotaxis|
|negative regulation by host of viral transcription|
|positive regulation of macrophage chemotaxis|
|positive regulation of T cell chemotaxis|
|negative regulation of myeloid cell apoptotic process|
|regulation of T cell chemotaxis|
|positive regulation of monocyte chemotaxis|
|positive regulation of lymphocyte apoptotic process|
|negative regulation of T cell apoptotic process|
|dendritic cell chemotaxis|
|macrophage migration|
|positive regulation of cell adhesion mediated by integrin|
|positive regulation of macrophage migration|
|eosinophil chemotaxis|
|dendritic cell migration|
|positive regulation of lymphocyte chemotaxis|
|eosinophil migration|
|positive regulation of mononuclear cell migration|
|regulation of monocyte chemotaxis|
|regulation of homotypic cell-cell adhesion|
|regulation of lymphocyte chemotaxis|
|negative regulation of viral transcription|
|regulation of macrophage chemotaxis|
|phosphatidylinositol phospholipase C activity|
|positive regulation of leukocyte apoptotic process|
|negative regulation of lymphocyte apoptotic process|
|CCR chemokine receptor binding|
|regulation of myeloid cell apoptotic process|
|positive regulation of translational initiation|
|positive regulation of T cell migration|
|regulation of T cell apoptotic process|
|lipopolysaccharide-mediated signaling pathway|
|positive regulation of viral genome replication|
|chemoattractant activity|
|regulation of macrophage migration|
|positive regulation of smooth muscle cell migration|
|positive regulation of lymphocyte migration|
|protein kinase B signaling|
|monocyte chemotaxis|
|regulation of granulocyte chemotaxis|
|regulation of T cell migration|
|negative regulation of leukocyte apoptotic process|
|regulation of cell adhesion mediated by integrin|
|regulation of mononuclear cell migration|
|negative regulation of G protein-coupled receptor signaling pathway|
|lymphocyte chemotaxis|
|positive chemotaxis|
|mononuclear cell migration|
|chemokine activity|
|leukocyte cell-cell adhesion|
|regulation of lymphocyte apoptotic process|
|positive regulation of protein tyrosine kinase activity|
|protein self-association|
|negative regulation of viral genome replication|
|positive regulation of phospholipase activity|
|regulation of smooth muscle cell migration|
|negative regulation of cytokine-mediated signaling pathway|
|positive regulation of viral life cycle|
|regulation of lymphocyte migration|
|regulation of viral transcription|
|negative regulation of response to cytokine stimulus|
|lymphocyte migration|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|regulation of tyrosine phosphorylation of STAT protein|
|regulation of translational initiation|
|chemokine-mediated signaling pathway|
|negative regulation of viral life cycle|
|regulation of leukocyte apoptotic process|
|neutrophil chemotaxis|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of leukocyte chemotaxis|
|regulation of protein tyrosine kinase activity|
|granulocyte chemotaxis|
|response to chemokine|
|cellular response to chemokine|
|neutrophil migration|
|regulation of viral genome replication|
|positive regulation of T cell proliferation|
|regulation of lipase activity|
|negative regulation of viral process|
|granulocyte migration|
|positive regulation of viral process|
|cellular response to fibroblast growth factor stimulus|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of leukocyte chemotaxis|
|response to fibroblast growth factor|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of calcium ion transport|
|positive regulation of translation|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of mononuclear cell proliferation|
|regulation of smooth muscle cell proliferation|
|regulation of receptor signaling pathway via STAT|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|regulation of G protein-coupled receptor signaling pathway|
|leukocyte chemotaxis|
|regulation of viral life cycle|
|protein tetramerization|
|positive regulation of cellular amide metabolic process|
|modification of morphology or physiology of other organism|
|regulation of T cell proliferation|
|cellular response to interferon-gamma|
|regulation of cytokine-mediated signaling pathway|
|cellular response to interleukin-1|
|regulation of response to cytokine stimulus|
|regulation of insulin secretion|
|response to interferon-gamma|
|cellular response to lipopolysaccharide|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|response to interleukin-1|
|positive regulation of T cell activation|
|regulation of viral process|
|regulation of lymphocyte proliferation|
|regulation of peptide hormone secretion|
|cell chemotaxis|
|regulation of mononuclear cell proliferation|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|negative regulation of multi-organism process|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of leukocyte proliferation|
|protein kinase activity|
|cellular response to tumor necrosis factor|
|regulation of calcium ion transport|
|calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|response to tumor necrosis factor|
|regulation of hormone secretion|
|positive regulation of ion transport|
|response to virus|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|regulation of leukocyte cell-cell adhesion|
|divalent inorganic cation transport|
|regulation of neuron death|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|regulation of epithelial cell proliferation|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|regulation of translation|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|leukocyte migration|
|regulation of metal ion transport|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|regulation of innate immune response|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|positive regulation of defense response|
|regulation of GTPase activity|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|response to toxic substance|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|positive regulation of cell death|
|regulation of ion transport|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|interspecies interaction between organisms|
|cation transport|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.77|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.77|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.76|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.77|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.95|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.06|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11583
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCL5 Expression in NALM6 Cells: 3.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>