CCM2L [The Human Chemical-Genetic Interaction Map Project]

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======= CCM2L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCM2L
  * **<color #00a2e8>Official Name</color>**: CCM2 like scaffold protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=140706|140706]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NUG4|Q9NUG4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCM2L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCM2L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of fibroblast growth factor production|
|regulation of fibroblast growth factor production|
|negative regulation of homotypic cell-cell adhesion|
|ventricular trabecula myocardium morphogenesis|
|regulation of homotypic cell-cell adhesion|
|cardiac muscle tissue growth|
|heart growth|
|cardiac atrium morphogenesis|
|heart trabecula morphogenesis|
|cardiac atrium development|
|trabecula morphogenesis|
|ventricular cardiac muscle tissue morphogenesis|
|ventricular cardiac muscle tissue development|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|muscle tissue morphogenesis|
|muscle organ morphogenesis|
|organ growth|
|negative regulation of protein binding|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|cytokine production|
|cardiac muscle tissue development|
|negative regulation of binding|
|cardiac chamber development|
|negative regulation of cell-cell adhesion|
|regulation of protein binding|
|heart morphogenesis|
|negative regulation of cell adhesion|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|regulation of binding|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|cellular component|
|positive regulation of cytokine production|
|muscle structure development|
|wound healing|
|heart development|
|tissue morphogenesis|
|response to wounding|
|regulation of cell adhesion|
|regulation of cytokine production|
|molecular function|
|circulatory system development|
|animal organ morphogenesis|
|negative regulation of molecular function|
|positive regulation of multicellular organismal process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.8|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.74|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3246
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCM2L Expression in NALM6 Cells: 1.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>