CCNA1 [The Human Chemical-Genetic Interaction Map Project]

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======= CCNA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNA1
  * **<color #00a2e8>Official Name</color>**: cyclin A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8900|8900]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78396|P78396]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604036|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. {ECO:0000269|PubMed:10022926}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin C|
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclin A1-CDK2 complex|
|cyclin A2-CDK2 complex|
|male meiosis I|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|cyclin-dependent protein kinase holoenzyme complex|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|male meiotic nuclear division|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|meiosis I|
|meiosis I cell cycle process|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|microtubule cytoskeleton|
|meiotic nuclear division|
|meiotic cell cycle process|
|meiotic cell cycle|
|protein kinase activity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|protein deubiquitination|
|nuclear division|
|protein modification by small protein removal|
|organelle fission|
|cellular process involved in reproduction in multicellular organism|
|protein kinase binding|
|cell division|
|regulation of protein serine/threonine kinase activity|
|spermatogenesis|
|male gamete generation|
|mitotic cell cycle process|
|mitotic cell cycle|
|gamete generation|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of kinase activity|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|cell cycle process|
|regulation of cell cycle|
|proteolysis|
|phosphorylation|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.73|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8653
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNA1 Expression in NALM6 Cells: -4.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>