CCNB1IP1 [The Human Chemical-Genetic Interaction Map Project]

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======= CCNB1IP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNB1IP1
  * **<color #00a2e8>Official Name</color>**: cyclin B1 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57820|57820]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPC3|Q9NPC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNB1IP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNB1IP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608249|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL- gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. {ECO:0000250, ECO:0000269|PubMed:12612082, ECO:0000269|PubMed:17297447}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chiasma assembly|
|synaptonemal complex|
|blastocyst formation|
|synapsis|
|reciprocal meiotic recombination|
|homologous recombination|
|homologous chromosome segregation|
|transferase activity|
|chromosome organization involved in meiotic cell cycle|
|meiotic chromosome segregation|
|blastocyst development|
|meiosis I|
|meiosis I cell cycle process|
|spermatid development|
|meiotic nuclear division|
|spermatid differentiation|
|meiotic cell cycle process|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|germ cell development|
|chromosome segregation|
|nuclear division|
|organelle fission|
|cellular process involved in reproduction in multicellular organism|
|in utero embryonic development|
|spermatogenesis|
|male gamete generation|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|protein ubiquitination|
|gamete generation|
|DNA metabolic process|
|protein modification by small protein conjugation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17840
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNB1IP1 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>