CCR5 [The Human Chemical-Genetic Interaction Map Project]

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======= CCR5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCR5
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine receptor 5 (gene/pseudogene)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1234|1234]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51681|P51681]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCR5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCR5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601373|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chemokine (C-C motif) ligand 5 binding|
|negative regulation of macrophage apoptotic process|
|multi-organism membrane fusion|
|fusion of virus membrane with host plasma membrane|
|membrane fusion involved in viral entry into host cell|
|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|release of sequestered calcium ion into cytosol by endoplasmic reticulum|
|multi-organism membrane organization|
|regulation of macrophage apoptotic process|
|sarcoplasmic reticulum calcium ion transport|
|negative regulation of myeloid cell apoptotic process|
|chemokine receptor activity|
|dendritic cell chemotaxis|
|dendritic cell migration|
|multi-organism cellular process|
|C-C chemokine receptor activity|
|C-C chemokine binding|
|chemokine binding|
|response to cholesterol|
|phosphatidylinositol phospholipase C activity|
|regulation of myeloid cell apoptotic process|
|response to sterol|
|coreceptor activity|
|negative regulation of leukocyte apoptotic process|
|cellular defense response|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|calcium ion transmembrane import into cytosol|
|calcium ion transport into cytosol|
|virus receptor activity|
|chemokine-mediated signaling pathway|
|regulation of leukocyte apoptotic process|
|cytosolic calcium ion transport|
|response to chemokine|
|cellular response to chemokine|
|viral entry into host cell|
|entry into host|
|entry into host cell|
|regulation of sequestering of calcium ion|
|membrane fusion|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|interaction with host|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|calcium ion transmembrane transport|
|viral life cycle|
|cell chemotaxis|
|cellular response to biotic stimulus|
|response to alcohol|
|calcium ion transport|
|actin binding|
|endosome|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|divalent inorganic cation transport|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|MAPK cascade|
|leukocyte migration|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|inflammatory response|
|cellular response to lipid|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cytokine-mediated signaling pathway|
|response to bacterium|
|viral process|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|cation transport|
|membrane organization|
|response to lipid|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|ion transmembrane transport|
|cell migration|
|protein phosphorylation|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|ion transport|
|integral component of plasma membrane|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|homeostatic process|
|regulation of cell death|
|intracellular signal transduction|
|establishment of localization in cell|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.86|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9898
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCR5 Expression in NALM6 Cells: 0.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>