CCRL2 [The Human Chemical-Genetic Interaction Map Project]

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======= CCRL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCRL2
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine receptor like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9034|9034]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00421|O00421]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCRL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCRL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608379|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chemokine receptor binding|
|chemokine receptor activity|
|C-C chemokine receptor activity|
|chemokine binding|
|C-C chemokine binding|
|CCR chemokine receptor binding|
|chemokine-mediated signaling pathway|
|cellular response to chemokine|
|response to chemokine|
|calcium-mediated signaling|
|cell chemotaxis|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|external side of plasma membrane|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|inflammatory response|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cytokine-mediated signaling pathway|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|cell migration|
|cellular response to cytokine stimulus|
|localization of cell|
|cell motility|
|response to cytokine|
|chemical homeostasis|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|homeostatic process|
|intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.74|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.8|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.88|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.9|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.94|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14647
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCRL2 Expression in NALM6 Cells: 3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>