CCT4 [The Human Chemical-Genetic Interaction Map Project]

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======= CCT4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCT4
  * **<color #00a2e8>Official Name</color>**: chaperonin containing TCP1 subunit 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10575|10575]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50991|P50991]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCT4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCT4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605142|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cpn60 TCP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA localization to nucleus|
|RNA localization to Cajal body|
|scaRNA localization to Cajal body|
|zona pellucida receptor complex|
|positive regulation of protein localization to Cajal body|
|regulation of protein localization to Cajal body|
|positive regulation of establishment of protein localization to telomere|
|chaperonin-containing T-complex|
|regulation of establishment of protein localization to telomere|
|positive regulation of protein localization to chromosome, telomeric region|
|regulation of establishment of protein localization to chromosome|
|regulation of protein localization to chromosome, telomeric region|
|positive regulation of telomerase RNA localization to Cajal body|
|regulation of telomerase RNA localization to Cajal body|
|positive regulation of telomere maintenance via telomerase|
|binding of sperm to zona pellucida|
|positive regulation of telomerase activity|
|positive regulation of telomere maintenance via telomere lengthening|
|toxin transport|
|positive regulation of telomere maintenance|
|regulation of telomerase activity|
|sperm-egg recognition|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|positive regulation of DNA biosynthetic process|
|cell-cell recognition|
|cell body|
|positive regulation of protein localization to nucleus|
|regulation of telomere maintenance|
|cell projection|
|melanosome|
|regulation of DNA biosynthetic process|
|regulation of protein localization to nucleus|
|unfolded protein binding|
|single fertilization|
|fertilization|
|positive regulation of chromosome organization|
|protein stabilization|
|positive regulation of DNA metabolic process|
|RNA localization|
|protein folding|
|cell recognition|
|regulation of protein stability|
|microtubule|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of establishment of protein localization|
|centrosome|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|regulation of establishment of protein localization|
|sexual reproduction|
|regulation of cellular localization|
|regulation of transferase activity|
|multi-organism reproductive process|
|regulation of protein localization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|RNA binding|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|ATP binding|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.99|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.99|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.87|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.8|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.75|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.7|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.74|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.86|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.88|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.92|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.95|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.97|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.01|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|2.11|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.12|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.52|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.473|
|[[:human genes:v:vasn|VASN]]|0.455|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 513
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCT4 Expression in NALM6 Cells: 8.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>