CD14 [The Human Chemical-Genetic Interaction Map Project]

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======= CD14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD14
  * **<color #00a2e8>Official Name</color>**: CD14 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=929|929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08571|P08571]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/158120|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). {ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:20133493, ECO:0000269|PubMed:23264655, ECO:0000269|PubMed:23880187, ECO:0000269|PubMed:8612135}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|opsonin receptor activity|
|response to triacyl bacterial lipopeptide|
|cellular response to triacyl bacterial lipopeptide|
|toll-like receptor TLR1:TLR2 signaling pathway|
|lipoteichoic acid binding|
|toll-like receptor TLR6:TLR2 signaling pathway|
|cellular response to diacyl bacterial lipopeptide|
|response to diacyl bacterial lipopeptide|
|lipopolysaccharide receptor complex|
|peptidoglycan receptor activity|
|cellular response to bacterial lipopeptide|
|response to bacterial lipopeptide|
|cellular response to bacterial lipoprotein|
|negative regulation of MyD88-independent toll-like receptor signaling pathway|
|response to bacterial lipoprotein|
|regulation of MyD88-independent toll-like receptor signaling pathway|
|lipopeptide binding|
|response to lipoteichoic acid|
|cellular response to lipoteichoic acid|
|positive regulation of interleukin-8 secretion|
|anchored component of external side of plasma membrane|
|toll-like receptor 4 signaling pathway|
|response to magnesium ion|
|necroptotic process|
|regulation of interleukin-8 secretion|
|programmed necrotic cell death|
|TRIF-dependent toll-like receptor signaling pathway|
|necrotic cell death|
|MyD88-dependent toll-like receptor signaling pathway|
|MyD88-independent toll-like receptor signaling pathway|
|lipopolysaccharide-mediated signaling pathway|
|lipopolysaccharide binding|
|negative regulation of toll-like receptor signaling pathway|
|response to electrical stimulus|
|positive regulation of interleukin-8 production|
|positive regulation of interferon-gamma production|
|regulation of toll-like receptor signaling pathway|
|regulation of interleukin-8 production|
|I-kappaB kinase/NF-kappaB signaling|
|positive regulation of NIK/NF-kappaB signaling|
|positive regulation of type I interferon production|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|secretory granule membrane|
|regulation of interferon-gamma production|
|toll-like receptor signaling pathway|
|positive regulation of endocytosis|
|regulation of NIK/NF-kappaB signaling|
|response to heat|
|response to ethanol|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|positive regulation of cytokine secretion|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|response to temperature stimulus|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|regulation of cytokine secretion|
|regulation of endocytosis|
|endosome membrane|
|cellular response to biotic stimulus|
|membrane raft|
|response to alcohol|
|innate immune response-activating signal transduction|
|receptor-mediated endocytosis|
|activation of innate immune response|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|apoptotic signaling pathway|
|positive regulation of peptide secretion|
|response to antibiotic|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|phagocytosis|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|response to metal ion|
|external side of plasma membrane|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|neutrophil mediated immunity|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|response to inorganic substance|
|regulation of vesicle-mediated transport|
|endocytosis|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|import into cell|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|exocytosis|
|regulation of secretion|
|response to lipid|
|positive regulation of immune response|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|Golgi apparatus|
|positive regulation of transport|
|secretion by cell|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell activation|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.88|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.7|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17437
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD14 Expression in NALM6 Cells: -0.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>