CD19 [The Human Chemical-Genetic Interaction Map Project]

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======= CD19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD19
  * **<color #00a2e8>Official Name</color>**: CD19 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=930|930]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15391|P15391]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107265|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|B-1 B cell differentiation|
|B cell proliferation involved in immune response|
|mature B cell differentiation|
|regulation of B cell receptor signaling pathway|
|positive regulation of phosphatidylinositol 3-kinase activity|
|positive regulation of lipid kinase activity|
|positive regulation of release of sequestered calcium ion into cytosol|
|B cell proliferation|
|B cell activation involved in immune response|
|positive regulation of phospholipid metabolic process|
|regulation of phosphatidylinositol 3-kinase activity|
|positive regulation of calcium ion transport into cytosol|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of lipid kinase activity|
|positive regulation of calcium ion transmembrane transport|
|regulation of release of sequestered calcium ion into cytosol|
|lymphocyte proliferation|
|regulation of phospholipid metabolic process|
|mononuclear cell proliferation|
|leukocyte proliferation|
|regulation of calcium ion transport into cytosol|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|regulation of complement activation|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|B cell receptor signaling pathway|
|regulation of humoral immune response|
|positive regulation of lipid metabolic process|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|B cell activation|
|positive regulation of ion transmembrane transport|
|positive regulation of protein kinase B signaling|
|positive regulation of transmembrane transport|
|immunoglobulin mediated immune response|
|regulation of B cell activation|
|B cell mediated immunity|
|regulation of protein kinase B signaling|
|membrane raft|
|lymphocyte differentiation|
|regulation of calcium ion transport|
|lymphocyte mediated immunity|
|positive regulation of ion transport|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of cytosolic calcium ion concentration|
|antigen receptor-mediated signaling pathway|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|regulation of cation transmembrane transport|
|lymphocyte activation|
|regulation of metal ion transport|
|external side of plasma membrane|
|regulation of lipid metabolic process|
|cellular calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|regulation of lymphocyte activation|
|cell population proliferation|
|cellular metal ion homeostasis|
|hemopoiesis|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|protein-containing complex|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|activation of immune response|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|immune system development|
|positive regulation of transferase activity|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|ion homeostasis|
|positive regulation of immune response|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cellular localization|
|leukocyte activation|
|regulation of transferase activity|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of phosphorylation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.3|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.21|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.04|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.73|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.73|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.75|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.79|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.83|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.84|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.84|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.86|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.91|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.94|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.96|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.98|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.99|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.05|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.26|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.26|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.33|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.42|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.44|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.47|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.48|
|[[:results:exp453|B02 10μM R08 exp453]]|2.56|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.62|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.65|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.71|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.75|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.75|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.85|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.94|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.96|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.98|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|3.15|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.26|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.49|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|3.86|
|[[:results:exp116|AICAR 240μM R03 exp116]]|4.04|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|4.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rhoh|RHOH]]|0.762|
|[[:human genes:p:pik3cd|PIK3CD]]|0.761|
|[[:human genes:s:syk|SYK]]|0.741|
|[[:human genes:r:rictor|RICTOR]]|0.691|
|[[:human genes:c:cd81|CD81]]|0.687|
|[[:human genes:i:igll1|IGLL1]]|0.674|
|[[:human genes:a:akt2|AKT2]]|0.668|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.666|
|[[:human genes:c:cd79b|CD79B]]|0.581|
|[[:human genes:c:cd79a|CD79A]]|0.577|
|[[:human genes:e:ergic1|ERGIC1]]|0.538|
|[[:human genes:g:ganab|GANAB]]|0.517|
|[[:human genes:a:akt1|AKT1]]|0.497|
|[[:human genes:p:pds5a|PDS5A]]|0.494|
|[[:human genes:p:pdpk1|PDPK1]]|0.482|
|[[:human genes:m:mlst8|MLST8]]|0.477|
|[[:human genes:b:bcl2l11|BCL2L11]]|0.471|
|[[:human genes:v:vezf1|VEZF1]]|0.436|
|[[:human genes:d:dph5|DPH5]]|0.428|
|[[:human genes:s:ssr3|SSR3]]|0.422|
|[[:human genes:g:gnas|GNAS]]|0.42|
|[[:human genes:m:midn|MIDN]]|0.416|
|[[:human genes:p:pmaip1|PMAIP1]]|0.412|
|[[:human genes:p:pacs1|PACS1]]|0.411|
|[[:human genes:w:wdr37|WDR37]]|0.407|
|[[:human genes:p:prrc2c|PRRC2C]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1944
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD19 Expression in NALM6 Cells: 8.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>