CD200R1 [The Human Chemical-Genetic Interaction Map Project]

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======= CD200R1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD200R1
  * **<color #00a2e8>Official Name</color>**: CD200 receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=131450|131450]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TD46|Q8TD46]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD200R1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD200R1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607546|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. {ECO:0000269|PubMed:12960329}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2-set 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immunoglobulin receptor activity|
|glycosylated region protein binding|
|negative regulation of T cell migration|
|negative regulation of macrophage migration|
|negative regulation of interleukin-6 secretion|
|negative regulation of neuroinflammatory response|
|negative regulation of lymphocyte migration|
|regulation of neuroinflammatory response|
|heterotypic cell-cell adhesion|
|regulation of macrophage migration|
|negative regulation of interleukin-6 production|
|regulation of T cell migration|
|negative regulation of leukocyte migration|
|regulation of lymphocyte migration|
|negative regulation of cytokine secretion|
|negative regulation of protein secretion|
|negative regulation of inflammatory response|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of leukocyte migration|
|negative regulation of secretion by cell|
|signaling receptor activity|
|receptor complex|
|regulation of cytokine secretion|
|negative regulation of neuron death|
|negative regulation of defense response|
|negative regulation of secretion|
|Fc receptor signaling pathway|
|negative regulation of cell migration|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|regulation of neuron death|
|negative regulation of locomotion|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|external side of plasma membrane|
|negative regulation of immune system process|
|regulation of protein secretion|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|regulation of peptide secretion|
|cell-cell adhesion|
|immune response-regulating signaling pathway|
|cell surface|
|regulation of cytokine production|
|viral process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|regulation of protein localization|
|regulation of response to external stimulus|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18822
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD200R1 Expression in NALM6 Cells: 0.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>