CD24 [The Human Chemical-Genetic Interaction Map Project]

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======= CD24 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD24
  * **<color #00a2e8>Official Name</color>**: CD24 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100133941|100133941]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25063|P25063]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD24&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD24|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600074|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). {ECO:0000250|UniProtKB:P24807, ECO:0000269|PubMed:11313396}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chemokine receptor transport out of membrane raft|
|negative regulation of transforming growth factor beta3 production|
|protein transport out of membrane raft|
|B cell receptor transport into membrane raft|
|chemokine receptor transport within lipid bilayer|
|B cell receptor transport within lipid bilayer|
|positive regulation of nephron tubule epithelial cell differentiation|
|glomerular parietal epithelial cell differentiation|
|regulation of transforming growth factor beta3 production|
|protein transport into membrane raft|
|protein localization to membrane raft|
|protein transport within lipid bilayer|
|positive regulation of epithelial cell differentiation involved in kidney development|
|negative regulation of transforming growth factor beta production|
|protein tyrosine kinase activator activity|
|regulation of nephron tubule epithelial cell differentiation|
|glomerular visceral epithelial cell differentiation|
|renal filtration cell differentiation|
|glomerular epithelial cell differentiation|
|regulation of epithelial cell differentiation involved in kidney development|
|anchored component of external side of plasma membrane|
|glomerular epithelium development|
|respiratory burst|
|positive regulation of activated T cell proliferation|
|epithelial cell differentiation involved in kidney development|
|regulation of transforming growth factor beta production|
|regulation of activated T cell proliferation|
|positive regulation of kidney development|
|cell differentiation involved in kidney development|
|glomerulus development|
|T cell costimulation|
|regulation of kidney development|
|lymphocyte costimulation|
|positive regulation of protein tyrosine kinase activity|
|positive regulation of epithelial cell differentiation|
|response to estrogen|
|cholesterol homeostasis|
|sterol homeostasis|
|localization within membrane|
|regulation of protein tyrosine kinase activity|
|positive regulation of T cell proliferation|
|nephron epithelium development|
|nephron development|
|kidney epithelium development|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|lipid homeostasis|
|positive regulation of leukocyte proliferation|
|regulation of epithelial cell differentiation|
|intrinsic apoptotic signaling pathway|
|regulation of T cell proliferation|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|membrane raft|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|positive regulation of MAP kinase activity|
|establishment of protein localization to membrane|
|kidney development|
|negative regulation of cytokine production|
|positive regulation of cytosolic calcium ion concentration|
|renal system development|
|apoptotic signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|urogenital system development|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to hypoxia|
|cell-cell signaling by wnt|
|response to decreased oxygen levels|
|Wnt signaling pathway|
|positive regulation of lymphocyte activation|
|response to oxygen levels|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|protein localization to membrane|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|cell-cell adhesion|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|epithelial cell differentiation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|regulation of protein kinase activity|
|membrane organization|
|regulation of kinase activity|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|intracellular protein transport|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|cell activation|
|cell motility|
|localization of cell|
|cell death|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|membrane|
</modal>
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 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13551
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD24 Expression in NALM6 Cells: 8.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>