CD2AP [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CD2AP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD2AP
  * **<color #00a2e8>Official Name</color>**: CD2 associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23607|23607]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5K6|Q9Y5K6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD2AP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD2AP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604241|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of transforming growth factor beta1 production|
|vascular endothelial growth factor receptor binding|
|negative regulation of transforming growth factor beta production|
|substrate-dependent cell migration, cell extension|
|regulation of transforming growth factor beta1 production|
|substrate-dependent cell migration|
|filamentous actin|
|regulation of transforming growth factor beta production|
|regulation of actin cytoskeleton reorganization|
|endocytic vesicle|
|negative regulation of small GTPase mediated signal transduction|
|positive regulation of protein localization to nucleus|
|beta-catenin binding|
|ruffle|
|regulation of receptor-mediated endocytosis|
|structural constituent of cytoskeleton|
|regulation of protein localization to nucleus|
|SH3 domain binding|
|cell-cell junction|
|protein C-terminus binding|
|regulation of endocytosis|
|actin cytoskeleton|
|actin filament organization|
|protein-containing complex binding|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|vesicle organization|
|cadherin binding|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein localization|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|proteasomal protein catabolic process|
|regulation of actin filament-based process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|plasma membrane bounded cell projection assembly|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cell division|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|modification-dependent macromolecule catabolic process|
|regulation of vesicle-mediated transport|
|actin filament-based process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|cell migration|
|positive regulation of transport|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.73|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.75|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.77|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7352
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD2AP Expression in NALM6 Cells: 6.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>