CD34 [The Human Chemical-Genetic Interaction Map Project]

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======= CD34 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD34
  * **<color #00a2e8>Official Name</color>**: CD34 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=947|947]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28906|P28906]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD34&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD34|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142230|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CD34 antigen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glomerular endothelium fenestra|
|negative regulation of cellular response to heat|
|extracellular exosome assembly|
|mesangial cell-matrix adhesion|
|positive regulation of glial cell-derived neurotrophic factor secretion|
|metanephric glomerular mesangial cell differentiation|
|metanephric mesangial cell differentiation|
|regulation of glial cell-derived neurotrophic factor secretion|
|positive regulation of granulocyte colony-stimulating factor production|
|glomerular endothelium development|
|metanephric glomerular mesangium development|
|positive regulation of macrophage colony-stimulating factor production|
|negative regulation of interleukin-2 secretion|
|sulfate binding|
|regulation of granulocyte colony-stimulating factor production|
|regulation of macrophage colony-stimulating factor production|
|vascular wound healing|
|metanephric glomerulus vasculature development|
|extracellular exosome biogenesis|
|glomerular mesangial cell differentiation|
|paracrine signaling|
|negative regulation of cellular response to hypoxia|
|regulation of interleukin-2 secretion|
|mesangial cell differentiation|
|transdifferentiation|
|glomerular mesangium development|
|pericyte cell differentiation|
|extracellular vesicle biogenesis|
|positive regulation of vasculogenesis|
|metanephric glomerulus development|
|glomerular filtration|
|positive regulation of odontogenesis|
|renal filtration|
|regulation of cellular response to hypoxia|
|hematopoietic stem cell proliferation|
|negative regulation of nitric oxide biosynthetic process|
|negative regulation of nitric oxide metabolic process|
|regulation of vasculogenesis|
|angiogenesis involved in wound healing|
|cell differentiation involved in metanephros development|
|glomerulus vasculature development|
|positive regulation of transforming growth factor beta production|
|renal system vasculature development|
|glomerular epithelium development|
|kidney vasculature development|
|negative regulation of interleukin-2 production|
|endothelial cell proliferation|
|regulation of odontogenesis|
|negative regulation of reactive oxygen species biosynthetic process|
|epithelial cell differentiation involved in kidney development|
|metanephric nephron development|
|basal plasma membrane|
|regulation of transforming growth factor beta production|
|positive regulation of interleukin-10 production|
|cell differentiation involved in kidney development|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|glomerulus development|
|negative regulation of coagulation|
|regulation of interleukin-10 production|
|stem cell proliferation|
|regulation of interleukin-2 production|
|negative regulation of reactive oxygen species metabolic process|
|regulation of nitric oxide biosynthetic process|
|intercellular bridge|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of cytokine secretion|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of cellular response to heat|
|regulation of hemostasis|
|positive regulation of animal organ morphogenesis|
|regulation of coagulation|
|metanephros development|
|regulation of reactive oxygen species biosynthetic process|
|negative regulation of response to wounding|
|epithelial cell proliferation|
|endothelium development|
|nephron epithelium development|
|renal system process|
|nephron development|
|cell-matrix adhesion|
|kidney epithelium development|
|negative regulation of protein secretion|
|regulation of wound healing|
|positive regulation of cytokine secretion|
|negative regulation of peptide secretion|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of angiogenesis|
|regulation of response to wounding|
|carbohydrate binding|
|regulation of reactive oxygen species metabolic process|
|negative regulation of protein transport|
|regulation of blood pressure|
|positive regulation of vasculature development|
|cell-substrate adhesion|
|negative regulation of establishment of protein localization|
|tissue homeostasis|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|negative regulation of neuron death|
|connective tissue development|
|negative regulation of secretion|
|lysosome|
|regulation of animal organ morphogenesis|
|kidney development|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|renal system development|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|vesicle organization|
|regulation of neuron death|
|angiogenesis|
|apical plasma membrane|
|urogenital system development|
|regulation of vasculature development|
|multicellular organismal homeostasis|
|transcription factor binding|
|anatomical structure homeostasis|
|regulation of neurotransmitter levels|
|negative regulation of response to external stimulus|
|leukocyte migration|
|extracellular structure organization|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|positive regulation of secretion by cell|
|blood vessel morphogenesis|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|wound healing|
|negative regulation of transport|
|blood vessel development|
|regulation of peptide secretion|
|regulation of body fluid levels|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|cell population proliferation|
|hemopoiesis|
|response to wounding|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|epithelial cell differentiation|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|organelle assembly|
|regulation of secretion|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|cell migration|
|positive regulation of cell differentiation|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|epithelium development|
|cell-cell signaling|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.09|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.83|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14528
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD34 Expression in NALM6 Cells: 2.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>