CD40LG [The Human Chemical-Genetic Interaction Map Project]

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======= CD40LG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD40LG
  * **<color #00a2e8>Official Name</color>**: CD40 ligand
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=959|959]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29965|P29965]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD40LG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD40LG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300386|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T- cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity). {ECO:0000250|UniProtKB:P27548, ECO:0000269|PubMed:1280226, ECO:0000269|PubMed:15067037, ECO:0000269|PubMed:8617933}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD40 receptor binding|
|immunoglobulin secretion|
|somatic recombination of immunoglobulin genes involved in immune response|
|isotype switching|
|somatic diversification of immunoglobulins involved in immune response|
|regulation of immunoglobulin secretion|
|positive regulation of endothelial cell apoptotic process|
|positive regulation of interleukin-4 production|
|somatic recombination of immunoglobulin gene segments|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|regulation of interleukin-4 production|
|tumor necrosis factor receptor binding|
|positive regulation of epithelial cell apoptotic process|
|positive regulation of interleukin-12 production|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|positive regulation of interleukin-10 production|
|somatic diversification of immunoglobulins|
|activation of JUN kinase activity|
|B cell proliferation|
|B cell activation involved in immune response|
|somatic diversification of immune receptors|
|regulation of endothelial cell apoptotic process|
|leukocyte cell-cell adhesion|
|regulation of interleukin-10 production|
|regulation of interleukin-12 production|
|T cell costimulation|
|lymphocyte costimulation|
|regulation of immunoglobulin production|
|positive regulation of JUN kinase activity|
|regulation of epithelial cell apoptotic process|
|JNK cascade|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|regulation of JUN kinase activity|
|positive regulation of T cell proliferation|
|leukocyte proliferation|
|stress-activated MAPK cascade|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|platelet activation|
|positive regulation of JNK cascade|
|regulation of production of molecular mediator of immune response|
|stress-activated protein kinase signaling cascade|
|positive regulation of NF-kappaB transcription factor activity|
|B cell activation|
|activation of MAPK activity|
|regulation of T cell proliferation|
|immunoglobulin production|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|peptide secretion|
|cytokine activity|
|production of molecular mediator of immune response|
|regulation of JNK cascade|
|positive regulation of T cell activation|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|DNA recombination|
|regulation of leukocyte proliferation|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|lymphocyte differentiation|
|cellular response to tumor necrosis factor|
|positive regulation of cell-cell adhesion|
|positive regulation of MAP kinase activity|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|regulation of T cell activation|
|activation of protein kinase activity|
|leukocyte differentiation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of lymphocyte activation|
|MAPK cascade|
|lymphocyte activation|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cytokine production|
|regulation of protein secretion|
|regulation of immune effector process|
|wound healing|
|regulation of peptide secretion|
|regulation of body fluid levels|
|inflammatory response|
|cell-cell adhesion|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|cell population proliferation|
|hemopoiesis|
|response to wounding|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|protein phosphorylation|
|regulation of transferase activity|
|negative regulation of cell death|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|response to cytokine|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|phosphorylation|
|defense response|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19048
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD40LG Expression in NALM6 Cells: -0.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>